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Cannabinoid

Original Wikipedia articleen.wikipedia.org/wiki/Cannabinoid revision used (24 October 2026)

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Overview

A cannabinoid is one of a class of diverse chemical compounds that act on cannabinoid receptors on cells that alter neurotransmitter functioning in the brain. These receptor proteins include the endocannabinoids (produced naturally in the body by humans and animals), the phytocannabinoids (found in cannabis and some other plants), and synthetic cannabinoids (manufactured chemically).[1] PW

Cannabinoids (/kəˈnæbənɔɪdz,_ˈkænəbənɔɪdz/) are several structural classes of compounds found primarily in the Cannabis plant or as synthetic compounds. Cannabinoids can be classified into two categories: major cannabinoids, which are present in high amounts in the Cannabis plant, and minor cannabinoids, which are present in smaller amounts in the Cannabis plant. The most notable and the most abundant major cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC). It is a primary psychoactive compound in Cannabis, capable of inducing the feeling of extreme euphoria and loss of memory. Cannabidiol (CBD) is a major constituent of temperate cannabis plants and a minor constituent in tropical varieties. Unlike THC, CBD is non-psychoactive and helps with anxiety and psychosis symptoms. Minor cannabinoids, such as cannabinol (CBN) and cannabichromene (CBC), have not been shown to induce any intoxicating or psychotropic effects. At least 113 distinct phytocannabinoids have been isolated from cannabis, although only four (THCA, CBDA, CBCA, and their common precursor CBGA) have a confirmed biogenetic origin. Phytocannabinoids are also found in other plants, such as rhododendron, licorice, and liverwort.[2–9] WP⚠ Part of this sentence could not be copied from the source. Open the source to read it in full.

Phytocannabinoids are multi-ring phenolic compounds structurally related to THC, while endocannabinoids are fatty acid derivatives. Nonclassical synthetic cannabinoids (cannabimimetics) include aminoalkylindoles, 1,5-diarylpyrazoles, quinolines, and arylsulfonamides, as well as eicosanoids related to endocannabinoids.[5][10] WP

Drugs in this class on intoxicant.wiki

Every page on this site that a cited source puts in this class: 26 pages. A drug is listed when its own PsychonautWiki, TripSit or Wikipedia entry names this class. Each name opens our page for that drug; long chemical names are shown by a shorter name the drug is also known by (hover for the full name).

Tags show who puts each drug in this class (hover for the exact wording): PW = the drug's PsychonautWiki entry; TS = the drug's TripSit entry (drug category); WP = the drug infobox of the drug's Wikipedia article. These are classifications only, not dosage guidance.

References

  1. Journal / agency Pacher, P., Bátkai, S., Kunos, G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacological Reviews. September 2006. doi:10.1124/pr.58.3.2
  2. Journal / agency Abyadeh M, Gupta V, Paulo JA, Gupta V, Chitranshi N, Godinez A, Saks D, Hasan M, Amirkhani A, McKay M, Salekdeh GH, Haynes PA, Graham SL, Mirzaei M. A Proteomic View of Cellular and Molecular Effects of Cannabis. Biomolecules. September 2021. doi:10.3390/biom11101411 · PMID 34680044 · PMC8533448
  3. Journal / agency Marijuana, also called: Cannabis, Ganja, Grass, Hash, Pot, Weed. 3 July 2017
  4. Journal / agency Walsh, Kenneth B.; McKinney, Amanda E.; Holmes, Andrea E. Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses. Frontiers in Pharmacology. 2021. doi:10.3389/fphar.2021.777804 · PMID 34916950 · PMC8669157
  5. Journal / agency Lambert DM, Fowler CJ. The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. Journal of Medicinal Chemistry. August 2005. doi:10.1021/jm058183t · PMID 16078824
  6. Other Cannabinoids. 2005
  7. Harm reduction site Bulletin on Narcotics – 1962 Issue 3 – 004. 1962-01-01
  8. Journal / agency Aizpurua-Olaizola O, Soydaner U, Öztürk E, Schibano D, Simsir Y, Navarro P, Etxebarria N, Usobiaga A. Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes. Journal of Natural Products. February 2016. doi:10.1021/acs.jnatprod.5b00949 · PMID 26836472
  9. Journal / agency Gülck T, Møller BL. Phytocannabinoids: Origins and Biosynthesis. Trends in Plant Science. October 2020. doi:10.1016/j.tplants.2020.05.005 · PMID 32646718
  10. Other Pate, DW (1999). Anandamide structure-activity relationships and mechanisms of action on intraocular pressure in the normotensive rabbit model. Kuopio University Publications A. Pharmaceutical Sciences Dissertation 37 ISBN 951-781-575-1

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