THJ-018
Also called 1-naphthalenyl(1-pentyl-1h-indazol-3-yl)-methanone
Dosage
Smoked bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
Smoked
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Duration
Smoked, drawn at the midpoint of each PsychonautWiki range.
Mixing
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
PsychonautWiki also lists dangerous combinations shared across a whole group (cannabis) in a table this page does not copy. Read that list on PsychonautWiki.
Risks and toxicity
The toxicity and long-term health effects of recreational THJ-018 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because THJ-018 has very little history of human usage. Anecdotal evidence from people who have tried THJ-018 within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer large amounts of anxiety or to fall asleep. PW
It has often been recommended that those with severe pre-existing mental conditions should not ingest these substances due to the way they strongly increase one's current state of mind and emotions. Also, like THC, prolonged usage of synthetic cannabinoids may increase one's disposition to mental illness and psychosis, particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).[3–6] PW
As synthetic cannabinoids are active in the milligram range (with below 5mg being a common dose), it is important to use proper precautions when dosing to avoid a negative experience. PW
It is strongly recommended that one use harm reduction practices when using this drug. PW
Tolerance and addiction potential
As with other synthetic cannibanoids, the chronic use of THJ-018 can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. PW
Tolerance to many of the effects of THJ-018 develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). THJ-018 presents cross-tolerance with all cannabinoids, meaning that after the consumption of THJ-018 all cannabinoids will have a reduced effect. PW
Toxicity
Although there is no valid data on the toxicity of synthetic cannabinoids so far, there is concern that the naphthalene group found in THJ-018 and some other synthetic cannabinoids may be toxic or carcinogenic.[7–10] PW
Testing
Effects
Overview
THJ-018 (1-naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone) is a synthetic cannabinoid and analog of JWH-018. It has been marketed by many research chemical vendors as a legal alternative to the popular JWH-018, which had been banned in 2009. Its appearance is a brown, sticky and chunky powder. It smells very similarly to naphthalene. Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. THJ-018 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids. PW
THJ-018 (SGT-17) is a synthetic cannabinoid that is the indazole analogue of JWH-018 and has been sold online as a designer drug.[1]
History
Legal status
- THJ-018 was developed to bypass drug prohibition laws which have banned the possession and sale of many synthetic cannabinoids. As such, it remains legal in most of the world. PW
- Germany: THJ-018 is controlled under Anlage II BtMG (Narcotics Act, Schedule II) as of May 23, 2015. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.[11]
[12] [13] PW - Latvia: THJ-018 is a Schedule I controlled substance.[14] PW
- Sweden: THJ-018 is banned in Sweden.[15] PW
- Switzerland: THJ-018 is a controlled substance specifically named under Verzeichnis E.[16] PW
- United Kingdom: THJ-018 is a Class B controlled substance under the third-generation synthetic cannabinoids generic definition, which came into effect on December 14, 2016 and is illegal to possess, produce, supply, or import.[17] PW
Legality
THJ-018 is an Anlage II controlled drug in Germany. It is also banned in Sweden.[15]
Pharmacology
Pharmacology
THJ-018 acts as a full agonist with a binding affinity of 5.84 nM at CB₁ and 4.57 nM at CB₂ cannabinoid receptors.[19] WP
Chemistry
User reports
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References
- Other THJ-018
- Journal / agency Diao X, Wohlfarth A, Pang S, Scheidweiler KB, Huestis MA. High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes. Clinical Chemistry. January 2016. doi:10.1373/clinchem.2015.243535 · PMID 26430074
- Journal / agency Arseneault, L., Cannon, M., Witton, J., Murray, R. M. Causal association between cannabis and psychosis: examination of the evidence. The British Journal of Psychiatry. February 2004. doi:10.1192/bjp.184.2.110
- Journal / agency Every-Palmer, S. Synthetic cannabinoid JWH-018 and psychosis: An explorative study. Drug and Alcohol Dependence. September 2011. doi:10.1016/j.drugalcdep.2011.01.012
- Journal / agency Schneir, A. B., Cullen, J., Ly, B. T. “Spice” Girls: Synthetic Cannabinoid Intoxication. The Journal of Emergency Medicine. 1 March 2011. doi:10.1016/j.jemermed.2010.10.014
- Journal / agency Vearrier, D., Osterhoudt, K. C. A Teenager With Agitation: Higher Than She Should Have Climbed. Pediatric Emergency Care. June 2010. doi:10.1097/PEC.0b013e3181e4f416
- Other http://www.epa.gov/ttn/atw/hlthef/naphthal.html
- Journal / agency Lin, C. Y., Wheelock, A. M., Morin, D., Baldwin, R. M., Lee, M. G., Taff, A., Plopper, C., Buckpitt, A., Rohde, A. Toxicity and metabolism of methylnaphthalenes: comparison with naphthalene and 1-nitronaphthalene. Toxicology. 16 June 2009. doi:10.1016/j.tox.2009.03.002
- Harm reduction site Synthetic cannabinoids in herbal products (United Nations Office on Drugs and Crime)
- Other Morris, H. HAMILTON MORRIS?: NAPTHALENE IS SO OVER. 2010
- Other Anlage II BtMG
- Other Neunundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften
- Other § 29 BtMG
- Other Zaudējis spēku - Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem
- Other http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/
- Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
- Other The Misuse of Drugs Act 1971 (Amendment) Order 2016
- Other Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)
- Journal / agency Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE. Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice. Forensic Toxicology. 2016. doi:10.1007/s11419-016-0320-2 · PMID 27429655 · PMC4929166
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