THJ-2201
Also called AM-2201 Indazole
Dosage
Smoked bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
Smoked
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Duration
Mixing
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
PsychonautWiki also lists dangerous combinations shared across a whole group (cannabis) in a table this page does not copy. Read that list on PsychonautWiki.
Risks and toxicity
The toxicity and long-term health effects of recreational THJ-2201 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because THJ-2201 has very little history of human usage. Anecdotal evidence from people who have tried THJ-2201 within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). PW
Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer moderate to severe anxiety or fall asleep. PW
It has often been recommended that those with severe pre-existing mental conditions should not ingest these substances due to the way they strongly increase one's current state of mind and emotions. Also, like THC, prolonged usage of synthetic cannabinoids may increase one's disposition to mental illness and psychosis, particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).[6–9] PW
As synthetic cannabinoids are active in the milligram range (with below 5mg being a common dose), it is important to use proper precautions when dosing to avoid a negative experience. PW
It is strongly recommended that one use harm reduction practices when using this drug. PW
Tolerance and addiction potential
As with other synthetic cannibanoids, the chronic use of THJ-2201 can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. PW
Tolerance to many of the effects of THJ-2201 develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). THJ-2201 presents cross-tolerance with all cannabinoids, meaning that after the consumption of THJ-2201 all cannabinoids will have a reduced effect. PW
Testing
Effects
Overview
THJ-2201 (1-[(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone) is a synthetic cannabinoid and analog of AM-2201. It has been marketed by many research chemical vendors as a legal alternative to the popular AM-2201, which had been banned in 2011. PW
THJ-2201 is an indazole-based synthetic cannabinoid that presumably acts as a potent agonist of the CB₁ receptor and has been sold online as a designer drug.[1–4] WP
It is a structural analog of AM-2201 in which the central indole ring has been replaced by indazole.[5] WP
History
Legal status
- THJ-2201 was developed to bypass drug prohibition laws which have banned the possession and sale of many synthetic cannabinoids. As such, it remains legal in most of the world. PW
- Denmark: As of August 25, 2015, THJ-2201 is listed on the list of controlled drugs in Denmark.[10] PW
- Germany: THJ-2201 is controlled under Anlage II BtMG (Narcotics Act, Schedule II) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.[11]
[12] [13] PW - Latvia: THJ-2201 is a Schedule I controlled substance.[14] PW
- Sweden: THJ-2201 is a controlled substance in Sweden.[15] PW
- Switzerland: THJ-018 is a controlled substance specifically named under Verzeichnis E.[16] PW
- United Kingdom: THJ-2201 is a Class B controlled substance under the third-generation synthetic cannabinoids generic definition, which came into effect on December 14, 2016 and is illegal to possess, produce, supply, or import.[17] PW
- United States: THJ-2201 is a Schedule I controlled substance.[18] PW
Legal status
It is classified as a Schedule I controlled substance in the United States.[18] WP
Pharmacology
Pharmacology
THJ-2201 acts as a full agonist with a binding affinity of 1.34 nM at CB₁ and 1.32 nM at CB₂ cannabinoid receptors.[20] WP
Chemistry
User reports
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References
- Journal / agency Diao X, Wohlfarth A, Pang S, Scheidweiler KB, Huestis MA. High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes. Clinical Chemistry. January 2016. doi:10.1373/clinchem.2015.243535 · PMID 26430074
- Journal / agency Shevyrin V, Melkozerov V, Nevero A, Eltsov O, Morzherin Y, Shafran Y. 3-Naphthoylindazoles and 2-naphthoylbenzoimidazoles as novel chemical groups of synthetic cannabinoids: chemical structure elucidation, analytical characteristics and identification of the first representatives in smoke mixtures. Forensic Science International. September 2014. doi:10.1016/j.forsciint.2014.06.022 · PMID 25036783
- Journal / agency Uchiyama N, Shimokawa Y, Kawamura M, Kikura-Hanajiri R, Hakamatsuka T. Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products. Forensic Toxicology. August 2014. doi:10.1007/s11419-014-0238-5
- Journal / agency Diao X, Scheidweiler KB, Wohlfarth A, Zhu M, Pang S, Huestis MA. Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes. Forensic Toxicology. 2016. doi:10.1007/s11419-016-0312-2 · PMID 27547265 · PMC4971051
- Other THJ-2201
- Journal / agency Arseneault, L., Cannon, M., Witton, J., Murray, R. M. Causal association between cannabis and psychosis: examination of the evidence. The British Journal of Psychiatry. February 2004. doi:10.1192/bjp.184.2.110
- Journal / agency Every-Palmer, S. Synthetic cannabinoid JWH-018 and psychosis: An explorative study. Drug and Alcohol Dependence. September 2011. doi:10.1016/j.drugalcdep.2011.01.012
- Journal / agency Schneir, A. B., Cullen, J., Ly, B. T. “Spice” Girls: Synthetic Cannabinoid Intoxication. The Journal of Emergency Medicine. 1 March 2011. doi:10.1016/j.jemermed.2010.10.014
- Journal / agency Vearrier, D., Osterhoudt, K. C. A Teenager With Agitation: Higher Than She Should Have Climbed. Pediatric Emergency Care. June 2010. doi:10.1097/PEC.0b013e3181e4f416
- Other Bekendtgørelse om euforiserende stoffer - ni nye stoffer tilføjet
- Other Anlage II BtMG
- Other Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften
- Other § 29 BtMG
- Other Zaudējis spēku - Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem
- Other http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/
- Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
- Other The Misuse of Drugs Act 1971 (Amendment) Order 2016
- Journal / agency Schedules of controlled substances: temporary placement of three synthetic cannabinoids into schedule I. Final order. PMID 25730924
- Other Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz - BtMG) Anlage II (zu § 1 Abs. 1) (verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel)
- Journal / agency Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE. Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice. Forensic Toxicology. 1 July 2016. doi:10.1007/s11419-016-0320-2 · PMID 27429655 · PMC4929166
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