STS-135
Also called 5F-APICA, N-(1-adamantyl)-1-(5-fluoropentyl)indole-3-carboxamide
Dosage
Smoked bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
Smoked
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | < 0.5 mg PW | 0.5–1.5 mg PW | 1.5–2 mg PW | 2–4 mg PW | 4 mg+ PW |
What dose are you on? (self-reported, unverified)
No reports yet.
Reports are anonymous, one per browser per day per route. Counts under 20 are shown but marked as too few to mean anything. Until accounts launch, reports stay in this browser only.
Duration
Smoked, drawn at the midpoint of each PsychonautWiki range.
Mixing
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
PsychonautWiki also lists dangerous combinations shared across a whole group (cannabis) in a table this page does not copy. Read that list on PsychonautWiki.
Risks and toxicity
The toxicity and long-term health effects of recreational STS-135 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because STS-135 has very little history of human usage. Anecdotal evidence from people who have tried STS-135 within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer large amounts of anxiety or to fall asleep. PW
It has often been recommended that those with severe pre-existing mental conditions should not ingest these substances due to the way they strongly increase one's current state of mind and emotions. Also, like THC, prolonged usage of synthetic cannabinoids may increase one's disposition to mental illness and psychosis, particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).[4–7] PW
As synthetic cannabinoids are active in the milligram range (with below 5mg being a common dose), it is important to use proper precautions when dosing to avoid a negative experience. PW
It is strongly recommended that one use harm reduction practices when using this drug. PW
Tolerance and addiction potential
As with other synthetic cannibanoids, the chronic use of STS-135 can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. PW
Tolerance to many of the effects of STS-135 develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). STS-135 presents cross-tolerance with all cannabinoids, meaning that after the consumption of STS-135 all cannabinoids will have a reduced effect. PW
Testing
Effects
Overview
STS-135 (also called N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide or 5F-APICA) is a drug that acts as a potent agonist for the cannabinoid receptors which produces subjective effects somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations. There is very little information regarding the pharmacology of this compound within the scientific literature. Despite this, however, it is available for sale as a grey area research chemical through online vendors. PW
STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA and ACBM-2201) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC₅₀ of 51 nM for human CB₂ receptors, and 13 nM for human CB₁ receptors. STS-135 produces bradycardia and hypothermia in rats at doses of 1–10 mg/kg, suggesting cannabinoid-like activity. It was first detected in 2013.[1]
History
Legal status
- STS-135 was developed to bypass drug prohibition laws which have banned the possession and sale of many synthetic cannabinoids. As such, it remains legal in many parts of the world. People may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume. PW
- China: As of October 2015, STS-135 is a controlled substance in China.[8] PW
- Germany: STS-135 is controlled under Anlage II BtMG (Narcotics Act, Schedule II) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.[9]
[10] [11] PW - Latvia: STS-135 is a Schedule I controlled substance.[12] PW
- Switzerland: STS-135 is a controlled substance specifically named under Verzeichnis E.[13] PW
- United Kingdom: STS-135 is a Class B controlled substance under the third-generation synthetic cannabinoids generic definition, which came into effect on December 14, 2016 and is illegal to possess, produce, supply, or import.[14] PW
Legal status
As of October 2015 STS-135 is a controlled substance in China. It is also illegal in the UK.[8] WP
Pharmacology
Detection
A forensic standard of STS-135 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[15] WP
Chemistry
User reports
Erowid erowid.org
ListingsBluelight bluelight.org
ListingsReddit reddit.com
ListingsPop culture
No references added yet.
Add a reference
Registered users can add songs, films, books, shows, games and art about this substance. Link a source that names the substance, such as the work's Wikipedia article, a review or an interview, not only the work itself. Entries are voted on and moderated like every other value on this page.
Opens when accounts launch.
References
- Journal / agency Wilkinson SM, Banister SD, Kassiou M. Bioisosteric Fluorine in the Clandestine Design of Synthetic Cannabinoids. Australian Journal of Chemistry. 2015. doi:10.1071/CH14198
- Journal / agency Banister SD, Stuart J, Kevin RC, Edington A, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Hibbs DE, Glass M, Connor M, McGregor IS, Kassiou M. Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135. ACS Chemical Neuroscience. August 2015. doi:10.1021/acschemneuro.5b00107 · PMID 25921407
- Journal / agency Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y. Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicology. 2013. doi:10.1007/s11419-013-0182-9
- Journal / agency Arseneault, L., Cannon, M., Witton, J., Murray, R. M. Causal association between cannabis and psychosis: examination of the evidence. The British Journal of Psychiatry. February 2004. doi:10.1192/bjp.184.2.110
- Journal / agency Every-Palmer, S. Synthetic cannabinoid JWH-018 and psychosis: An explorative study. Drug and Alcohol Dependence. September 2011. doi:10.1016/j.drugalcdep.2011.01.012
- Journal / agency Schneir, A. B., Cullen, J., Ly, B. T. “Spice” Girls: Synthetic Cannabinoid Intoxication. The Journal of Emergency Medicine. 1 March 2011. doi:10.1016/j.jemermed.2010.10.014
- Journal / agency Vearrier, D., Osterhoudt, K. C. A Teenager With Agitation: Higher Than She Should Have Climbed. Pediatric Emergency Care. June 2010. doi:10.1097/PEC.0b013e3181e4f416
- Journal / agency 关于印发《非药用类麻醉药品和精神药品列管办法》的通知
- Other Anlage II BtMG
- Other Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften
- Other § 29 BtMG
- Other Zaudējis spēku - Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem
- Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
- Other The Misuse of Drugs Act 1971 (Amendment) Order 2016
- Other Southern Association of Forensic Scientists
Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.