Cannabinoid

Tetrahydrocannabihexol

Also called THCH, n-Hexyl-delta-9-thc

Original Wikipedia articleen.wikipedia.org/wiki/Tetrahydrocannabihexol revision used (24 October 2026)

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Overview

Tetrahydrocannabihexol (THCH) is a phytocannabinoid. PW

Tetrahydrocannabihexol (Δ⁹-THCH, Δ⁹-Parahexyl, n-Hexyl-Δ⁹-THC) is a phytocannabinoid, the hexyl homologue of tetrahydrocannabinol (THC) which was first isolated from Cannabis plant material in 2020 along with the corresponding hexyl homologue of cannabidiol, though it had been known for several decades prior to this as an isomer of the synthetic cannabinoid parahexyl. Another isomer Δ⁸-THCH is also known as a synthetic cannabinoid under the code number JWH-124, though it is unclear whether this occurs naturally in Cannabis, but likely is due to Δ⁸-THC itself being a degraded form of Δ⁹-THC. THC-Hexyl can be synthesized from 4-hexylresorcinol and was studied by Roger Adams as early as 1942.[1–6] WP

History

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Pharmacology

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Chemistry

Formula: C22H32O2 PC
CAS number: 36482-24-3 PC
Molar mass (g/mol): 328.5 PC
IUPAC name (computed by PubChem): (6aR,10aR)-3-hexyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol PC
SMILES: CCCCCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O PC
InChIKey: DMJVNNFBMZZLFB-QZTJIDSGSA-N PC
PubChem CID: 161906

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References

Journal / agency Linciano P, Citti C, Russo F, Tolomeo F, Laganà A, Capriotti AL, Luongo L, Iannotta M, Belardo C, Maione S, Forni F, Vandelli MA, Gigli G, Cannazza G. Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol. Scientific Reports. December 2020. doi:10.1038/s41598-020-79042-2 · PMID 33328530 · PMC7744557
Journal / agency Radwan MM, Chandra S, Gul S, ElSohly MA. Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis. Molecules. May 2021. doi:10.3390/molecules26092774 · PMID 34066753 · PMC8125862
Journal / agency Brown NK, Harvey DJ. Metabolism of n-hexyl-homologues of delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in the mouse. European Journal of Drug Metabolism and Pharmacokinetics. 1988. doi:10.1007/BF03189936 · PMID 2853671
Journal / agency Martin BR, Jefferson R, Winckler R, Wiley JL, Huffman JW, Crocker PJ, Saha B, Razdan RK. Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists. The Journal of Pharmacology and Experimental Therapeutics. September 1999. PMID 10454479
Journal / agency Bow EW, Rimoldi JM. The Structure-Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation. Perspectives in Medicinal Chemistry. 2016. doi:10.4137/PMC.S32171 · PMID 27398024 · PMC4927043
Journal / agency Adams R, Loewe S, Smith CM, McPhee WD. Tetrahydrocannabinol Homologs and Analogs with Marihuana Activity. XIII¹. Journal of the American Chemical Society. 1942. doi:10.1021/ja01255a061

Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.