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Depressant

Prazepam

Also called Centrac, Centrax, Demetrin, Lysanxia, Pozapam, Prasepine, Prazene, Reapam, Trepidan, Verstran, Sedapran, Settima

Original Wikipedia articleen.wikipedia.org/wiki/Prazepam revision used (24 October 2026)

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Part of the metabolic pathway of Prazepam. See the timeline on the metabolic highway.

Common dose · Oral10–20 mg TS

Dosage

Oral

SourceThresholdLightCommonStrongHeavy
TripSit–5–10 mg TS10–20 mg TS20–40 mg. TS–

TripSit dose text

TripSit's factsheet also states its doses as text.

Light: 5-10mg Common: 10-20mg Strong: 20-40mg. TS

What dose are you on? (self-reported, unverified)
Read this first. These numbers come from anonymous visitors typing in a box. Nobody checks them. People misjudge, mistype, troll, or take untested products of unknown strength. They are not a dose guide and never override the sourced table above. They exist only so the sourced ranges can be compared with what people say they take. If you are deciding what to take, use the sourced table, start low, and read the risks section.
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Duration

TripSit factsheet

Onset
45-120 minutes TS
Duration
8-20 hours TS
Aftereffects
8-24 hours TS

Mixing

For best safety practice, don't mix this drug with other depressants.

Why: respiratory depression. PsychonautWiki says:

Quotes from PsychonautWiki, CC BY-SA 4.0.

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

TripSit combination chart

TripSit rates each pairing. Only pairings with a number carry a citation from TripSit. See the whole chart; TripSit's own notes are on combo.tripsit.me.

Dangerous

alcohol TStramadol TS

Unsafe

pcp TS

Caution

dextromethorphan TSketamine TSmxe TS

Low Risk & Decrease

amt TScaffeine TScannabis TScocaine TSdmt TSlsd TSmdma TSmescaline TSmushrooms TSnitrous TS

Risks and toxicity

TripSit factsheet

Avoid
All other CNS depressants, and Cimetidine TS

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

AnxiolyticAnticonvulsantSedativeSkeletal Muscle Relaxant TS

Overview

Benzodiazepine dervative. Has all the normal benzodiazepine-like quality (Anxiolytic/anticonvulsant/sedative/Skeletal muscle relaxant) It is also a prodrug for Desmethyldiazepam which is responsible for most if not all of the effects of Prazepam. TS

Prazepam is a benzodiazepine derivative drug developed by Warner-Lambert in the 1960s. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Prazepam, (Elimination half-life 29-224h), is a prodrug for desmethyldiazepam, (Elimination half-life 36-200h), which is responsible for the therapeutic effects of prazepam.[1][2][3] WP

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Pharmacology

Mechanism of action

Prazepam exerts its therapeutic effects primarily via modulating the benzodiazepine site which in turn enhances GABA function in the brain. Prazepam like other benzodiazepines has anticonvulsant properties, but its anticonvulsant properties are not as potent as other benzodiazepines when tested in animal studies.[4–8] WP

Pharmacokinetics

Prazepam is metabolised into descyclopropylmethylprazepam (also known as desmethyldiazepam) and 3-hydroxyprazepam which is further metabolised into oxazepam. Prazepam is a prodrug for descyclopropylmethylprazepam/desmethyldiazepam (also known as norprazepam or nordazepam) which is responsible for most of the therapeutic activity of prazepam rather than prazepam itself.[4][9–16] WP

Chemistry

Formula
C19H17ClN2O PC
CAS number
2955-38-6 PC
Molar mass (g/mol)
324.8 PC
IUPAC name (computed by PubChem)
7-chloro-1-(cyclopropylmethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one PC
SMILES
C1CC1CN2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4 PC
InChIKey
MWQCHHACWWAQLJ-UHFFFAOYSA-N PC
PubChem CID
4890
IUPAC name
7-Chloro-1-(cyclopropylmethyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one WP

User reports

Erowid erowid.org

Listings
Awaiting sourceExperience Vault listing and report categories.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Bluelight bluelight.org

Listings
Awaiting sourceTrip report threads and this substance's discussion forum.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Reddit reddit.com

Listings
Awaiting sourceTrip report posts and the relevant subreddits.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Pop culture

No references added yet.

Add a reference

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References

  1. Other US Patent 3192199 – Process for the production of I-CYCLO- ALKYL derivatives of I,X-BENZODIAZEPINE
  2. Journal / agency Shader RI, Greenblatt DJ. Ciba Foundation Symposium 74 - Drug Concentrations in Neuropsychiatry. Ciba Foundation Symposium. 1979. doi:10.1002/9780470720578.ch9 · PMID 45081
  3. Journal / agency Jacqmin P, Ansseau M. Comparison of sublingual and oral prazepam in normal subjects. II. Pharmacokinetic and pharmacodynamic data. Neuropsychobiology. 1988. doi:10.1159/000118458 · PMID 2854609
  4. Journal / agency Quast U. Molecular mechanism of action of benzodiazepines. Fortschritte der Medizin. May 1981. PMID 6114911
  5. Journal / agency De Sarro G, Gitto R, Rizzo M, Zappia M, De Sarro A. 1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice. General Pharmacology. September 1996. doi:10.1016/0306-3623(95)02147-7 · PMID 8909973
  6. Journal / agency De Sarro G, Chimirri A, Zappala M, Guisti P, Lipartiti M, De Sarro A. Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice. General Pharmacology. October 1996. doi:10.1016/S0306-3623(96)00049-3 · PMID 8981061
  7. Journal / agency De Sarro G, Chimirri A, McKernan R, Quirk K, Giusti P, De Sarro A. Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice. Pharmacology, Biochemistry, and Behavior. September 1997. doi:10.1016/S0091-3057(96)00565-5 · PMID 9264104
  8. Journal / agency Fukinaga M, Ishizawa K, Kamei C. Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action. Pharmacology. November 1998. doi:10.1159/000028247 · PMID 9742288
  9. Journal / agency Viau JP, Epps JE, Di Carlo J. Prazepam metabolism after chronic administration to humans. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. September 1973. doi:10.3109/00498257309151546 · PMID 4763144
  10. Journal / agency Valavani P, Atta-Politou J, Panderi I. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the quantitation of prazepam and its main metabolites in human plasma. Journal of Mass Spectrometry. April 2005. doi:10.1002/jms.824 · PMID 15712230
  11. Journal / agency Lu XL, Guengerich FP, Yang SK. Stereoselective metabolism of prazepam and halazepam by human liver microsomes. Drug Metabolism and Disposition. 1991. doi:10.1016/S0090-9556(25)07201-0 · PMID 1680631
  12. Journal / agency Greenblatt DJ, Shader RI. Prazepam, a precursor of desmethyldiazepam. Lancet. April 1978. doi:10.1016/S0140-6736(78)90834-6 · PMID 76260
  13. Journal / agency Nau H, Liddiard C, Jesdinsky D, Wittfoht W. Quantitative analysis of prazepam and its metabolites by electron capture gas chromatography and selected ion monitoring. Application to diaplacetal passage and fetal hepatic metabolism in early human pregnancy. Journal of Chromatography. September 1978. doi:10.1016/S0378-4347(00)81889-7 · PMID 701422
  14. Journal / agency Shader RI, Greenblatt DJ. The use of benzodiazepines in clinical practice. British Journal of Clinical Pharmacology. 1981. doi:10.1111/j.1365-2125.1981.tb01832.x · PMID 6133535 · PMC1401641
  15. Journal / agency Kölle EU. Pharmacokinetics of oral prazepam. Fortschritte der Medizin. June 1981. PMID 6790396
  16. Journal / agency Ochs HR, Greenblatt DJ, Verburg-Ochs B, Locniskar A. Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam. Journal of Clinical Pharmacology. October 1984. doi:10.1002/j.1552-4604.1984.tb01817.x · PMID 6150943

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.