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Depressant

Pinazepam

Also called Domar, Duna

Original Wikipedia articleen.wikipedia.org/wiki/Pinazepam revision used (24 October 2026)

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Part of the metabolic pathway of Pinazepam. See the timeline on the metabolic highway.

Common dose · Oral5–10 mg TS

Dosage

Oral

SourceThresholdLightCommonStrongHeavy
TripSit–2.5–5 mg TS5–10 mg TS10–20 mg+ TS–

TripSit dose text

TripSit's factsheet also states its doses as text.

Light: 2.5-5mg Common: 5-10mg Strong: 10-20mg+ TS

What dose are you on? (self-reported, unverified)
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Duration

TripSit factsheet

Onset
15-90 minutes TS
Duration
6-16 hours TS
Aftereffects
2-10 hours TS

Mixing

For best safety practice, don't mix this drug with other depressants.

Why: respiratory depression. PsychonautWiki says:

Quotes from PsychonautWiki, CC BY-SA 4.0.

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

TripSit combination chart

TripSit rates each pairing. Only pairings with a number carry a citation from TripSit. See the whole chart; TripSit's own notes are on combo.tripsit.me.

Dangerous

alcohol TStramadol TS

Unsafe

pcp TS

Caution

dextromethorphan TSketamine TSmxe TS

Low Risk & Decrease

amt TScaffeine TScannabis TScocaine TSdmt TSlsd TSmdma TSmescaline TSmushrooms TSnitrous TS

Risks and toxicity

TripSit factsheet

Avoid
All CNS depressants. TS

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

Awaiting sourceSubjective and physical effects from PsychonautWiki or TripSit.

Overview

Benzodiazepine that is solely an anxiolytic drug that lacks the hypnotic and motor impairment that most benzodiazepines do. The main metabolite of this is Nordazepam and to a lesser effect Oxazepam, which is where it gets most of its effects TS

Pinazepam (marketed under the brand name Domar and Duna) is a benzodiazepine drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.[1][2] WP

Pinazepam and its metabolite N-desmethyldiazepam are transferred to the developing fetus in utero, but the plasma drug level in the mother is usually significantly higher than in the fetus.[3] WP

Pinazepam differs from other benzodiazepines in that it has a propargyl group at the N-1 position of the benzodiazepine structure. It is less toxic than diazepam and in animal studies it appears to produce anxiolytic and anti-agitation properties with limited hypnotic and motor coordination impairing properties. Pinazepam is rapidly absorbed after oral administration. The main active metabolites of pinazepam are depropargylpinazepam (N-desmethyldiazepam, nordazepam) and oxazepam. In humans pinazepam acts as a pure anxiolytic agent in that it does not possess to any significant degree the other pharmacological characteristics of benzodiazepines. Its lack of intellectual, motor and hypnotic impairing effects makes it more appropriate than other benzodiazepines for day time use. The elimination half-life is longer in the elderly.[2][4–8] WP

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Pharmacology

Awaiting sourcePharmacology from Wikipedia and the journal papers it cites.

Chemistry

Formula
C18H13ClN2O PC
CAS number
52463-83-9 PC
Molar mass (g/mol)
308.8 PC
IUPAC name (computed by PubChem)
7-chloro-5-phenyl-1-prop-2-ynyl-3H-1,4-benzodiazepin-2-one PC
SMILES
C#CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3 PC
InChIKey
MFZOSKPPVCIFMT-UHFFFAOYSA-N PC
PubChem CID
40391
IUPAC name
7-chloro-5-phenyl-1-prop-2-yn-1-yl-1,3-dihydro-2H-1,4-benzodiazepin-2-one WP

User reports

Erowid erowid.org

Listings
Awaiting sourceExperience Vault listing and report categories.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Bluelight bluelight.org

Listings
Awaiting sourceTrip report threads and this substance's discussion forum.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Reddit reddit.com

Listings
Awaiting sourceTrip report posts and the relevant subreddits.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Pop culture

No references added yet.

Add a reference

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References

  1. Journal / agency Schütz H, Holland EM, Kazemian-Erdmann F, Schölermann K. Screening of the new benzodiazepine derivative, pinazepan, and its major metabolites. Arzneimittel-Forschung. September 1988. PMID 3146986
  2. Journal / agency Janbroers, J. M. Pinazepam: review of pharmacological properties and therapeutic efficacy. Clinical Therapeutics. 1984. PMID 6147192
  3. Journal / agency Pacifici GM, Cuoci L, Guarneri M, Fornaro P, Arcidiacono G, Cappelli N, Moggi G, Placidi GF. Placental transfer of pinazepam and its metabolite N-desmethyldiazepam in women at term. European Journal of Clinical Pharmacology. 1984. doi:10.1007/BF00542165 · PMID 6150857
  4. Other Diazepam Injection BP - Summary of Product Characteristics (SmPC) - (emc)
  5. Journal / agency Dinis-Oliveira, Ricardo Jorge. Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metabolism Reviews. Sep 14, 2017. doi:10.1080/03602532.2017.1377223 · PMID 28903606
  6. Journal / agency Pacifici GM, Placidi GF, Fornaro P, Gomeni R. Pharmacokinetics of pinazepam in healthy volunteers. International Journal of Clinical Pharmacology Research. 1983. PMID 6147314
  7. Journal / agency Pacifici GM, Placidi GF, Fornaro P, Gomeni R. Pinazepam: a precursor of N-desmethyldiazepam. European Journal of Clinical Pharmacology. 1982. doi:10.1007/BF00545219 · PMID 6809477
  8. Journal / agency Pacifici GM, Cuoci L, Placidi GF, Fornaro P, Gomeni R. Elimination kinetics of desmethyldiazepam in two young and two elderly subjects. European Journal of Drug Metabolism and Pharmacokinetics. Jan 1982. doi:10.1007/bf03189546 · PMID 6802645

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.