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Compound

Norquetiapine

Original Wikipedia articleen.wikipedia.org/wiki/Norquetiapine revision used (24 October 2026)

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Part of the metabolic pathway of Quetiapine. See the timeline on the metabolic highway.

Overview

Norquetiapine, also known as N-desalkylquetiapine, is a 5-HT2B serotonin receptor modulator, and norepinephrine reuptake inhibitor. It is the principal metabolite of quetiapine.[1–6] WP

Chemistry

Formula
C17H17N3S PC
CAS number
5747-48-8 PC
Molar mass (g/mol)
295.4 PC
IUPAC name (computed by PubChem)
6-piperazin-1-ylbenzo[b][1,4]benzothiazepine PC
SMILES
C1CN(CCN1)C2=NC3=CC=CC=C3SC4=CC=CC=C42 PC
InChIKey
JLOAJISUHPIQOX-UHFFFAOYSA-N PC
PubChem CID
11369918

Harm reduction information

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Sources

  1. Other CAS Common Chemistry
  2. Journal / agency Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology. September 2008. doi:10.1038/SJ.NPP.1301646 · PMID 18059438
  3. Journal / agency Di Benedetto B, Kühn R, Nothdurfter C, Rein T, Wurst W, Rupprecht R. N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant. Neuropharmacology. January 2012. doi:10.1016/j.neuropharm.2011.07.001 · PMID 21767553
  4. Other Brunton L, Chabner B, Knollman B. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 2010
  5. Journal / agency PubChem. Quetiapine
  6. Other Norquetiapine

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.