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Quetiapine

What the body does with Quetiapine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

QuetiapinetakenNorquetiapinemetaboliteExitKidney (73%), feces (20%)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    100% 1

  2. hoursbreakdown

    Metabolism

    Liver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine) 1

  3. hoursfrom the article text

    What else it turns into

    “The major active metabolite of quetiapine is norquetiapine (N-desalkylquetiapine).” 2

  4. half-lifehalf gone

    Elimination half-life

    7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine) 1

  5. exitleaves the body

    Excretion

    Kidney (73%), feces (20%) 1

Sources

  1. Wikipedia, Quetiapine, drug infobox (revision 1372676814), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Quetiapine, article text (revision 1372676814), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.