Zolazepam
Also called Zolasepam, Flupyrazapon
Dosage
Insufflated
Intramuscular
Oral
TripSit dose text
TripSit's factsheet also states its doses as text.
Oral Light: 2.5-5mg Common: 5-10mg Strong: 10-20mg+ | Insufflated Light: 1-3mg Common: 3-6mg Strong: 6-12mg+ | Intramuscular Light: 1-3mg Common: 3-5mg Strong: 5-10mg+ TS
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Duration
TripSit factsheet
Mixing
For best safety practice, don't mix this drug with other depressants.
Why: respiratory depression. PsychonautWiki says:
- “Respiratory depression (also known as hypoventilation) can be described as a reduced urge to breathe that can be fatal depending on its intensity.” (PsychonautWiki, Respiratory depression, revision 150612)
- “... otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant. For example, benzodiazepines combined with opioids are an extremely common cause of fatal respiratory depression. It is therefore strongly discouraged to combine these depressants at any dosage range.” (PsychonautWiki, Respiratory depression, revision 150612)
- “The most common cause of substance-related deaths is the combination of depressants (such as opiates, benzodiazepines, or alcohol) with other depressants.” (PsychonautWiki, Responsible drug use, revision 168206)
- “This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration.” (PsychonautWiki, dangerous interactions table, "Depressants" row, revision 156847)
Quotes from PsychonautWiki, CC BY-SA 4.0.
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
TripSit combination chart
TripSit rates each pairing. Only pairings with a number carry a citation from TripSit. See the whole chart; TripSit's own notes are on combo.tripsit.me.
Caution
Risks and toxicity
TripSit factsheet
- Avoid
- All other CNS depressants. TS
Testing
Effects
Overview
A substance that is structurally related to benzodiazepines. Is only used in Veterinary medicine. It is usually used in tandem with either the potent NMDA antagonist Tiletamine (at a 1:1 ratio) or with the α2 adrenergic receptor agonist Xylazine. Is roughly around four times the potency of Diazepam. Yet is water soluable. TS
Zolazepam (Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the α2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for. It has 5-10 times the potency of diazepam.[1]
Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke-Davis and was the result of a very detailed analysis of the benzodiazepine structure (U.S. patent 3,558,605 filed in 1969).[3] WP
Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be superior to ketamine because of reduced side-effects. A 1:1 mixture of zolazepam and tiletamine is sold under the names Telazol and Zoletil.[4]
History
Legal status
Pharmacology
Chemistry
- Formula
- C15H15FN4O PC
- CAS number
- 31352-82-6 PC
- Molar mass (g/mol)
- 286.30 PC
- IUPAC name (computed by PubChem)
- 4-
(2- PCfluorophenyl) - 1, 3, 8- trimethyl- 6H- pyrazolo[5, 4- e] [1, 4] diazepin- 7- one - SMILES
- CC1=NN(C2=C1C(=NCC(=O)
N2C) PCC3=CC=CC=C3F) C - InChIKey
- GDSCFOSHSOWNDL-
UHFFFAOYSA- PCN - PubChem CID
- 35775
- IUPAC name
- 4-
(2- WPfluorophenyl) - 1, 3, 8- trimethyl- 6H- pyrazolo
User reports
Erowid erowid.org
ListingsBluelight bluelight.org
ListingsReddit reddit.com
ListingsPop culture
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References
- Other Anesthetic compositions and methods of use
- Journal / agency DeWald HA, Lobbestael S, Butler DE. Pyrazolodiazepines. 2. 4-Aryl-1,3-dialkyl-6,8-dihydropyrazolo[3,4-e][1,4]diazepin-7(1H)-ones as antianxiety and anticonvulsant agents. Journal of Medicinal Chemistry. December 1977. doi:10.1021/jm00222a005 · PMID 22748
- Other Pyrazolo[3,4-e],[1,4]diazepin-7(1H)-on Verbindungen und ihre pharmazeutisch zulässigen Salze [Pyrazolo[3,4-e],[1.4]diazepin-7(lH)-one compounds and their pharmaceutically acceptable salts]
- Journal / agency Sleeman JM, Cameron K, Mudakikwa AB, Nizeyi JB, Anderson S, Cooper JE, Richardson HM, Macfie EJ, Hastings B, Foster JW. Field anesthesia of free-living mountain gorillas (Gorilla gorilla beringei) from the Virunga Volcano region, Central Africa. Journal of Zoo and Wildlife Medicine. March 2000. doi:10.1638/1042-7260(2000)031[0009:faoflm]2.0.co;2 · PMID 10884117
- Journal / agency Cattet MR, Caulkett NA, Polischuk SC, Ramsay MA. Anesthesia of polar bears (Ursus maritimus) with zolazepam-tiletamine, medetomidine-ketamine, and medetomidine-zolazepam-tiletamine. Journal of Zoo and Wildlife Medicine. September 1999. PMID 10572857
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.