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Dissociative

Tiletamine

Also called Telazol

Original Wikipedia articleen.wikipedia.org/wiki/Tiletamine revision used (24 October 2026)

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Part of the metabolic pathway of Tiletamine. See the timeline on the metabolic highway.

Common dose · Intramuscular5–10 mg TS

Dosage

Intramuscular

SourceThresholdLightCommonStrongHeavy
TripSit–2.5–5 mg TS5–10 mg TS10–20 mg+ TS–

Oral

SourceThresholdLightCommonStrongHeavy
TripSit–10–25 mg TS25–50 mg TS50–100 mg+ TS–

TripSit dose text

TripSit's factsheet also states its doses as text.

Oral Light: 10-25mg Common: 25-50mg Strong: 50-100mg+ | Intramuscular Light: 2.5-5mg Common: 5-10mg Strong: 10-20mg+ TS

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Duration

TripSit factsheet

Onset
Insufflated: 2-10 minutes · Intramuscular: 1-5 minutes · Oral: 15-45 minutes TS
Duration
Insufflated: 2-5 hours · Intramuscular: 1-4 hours · Oral: 6-12 hours TS
Aftereffects
1-72 hours TS

Mixing

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

Risks and toxicity

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Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

Awaiting sourceSubjective and physical effects from PsychonautWiki or TripSit.

Overview

A relatively rare dissociative anesthetic, pharmacologically classified as an NMDA receptor antagonist. It is related to other anesthetics in this family such as Ketamine and phencyclidine. Has been used to cut Ketamine, in which case it may cause additional nausea. In Veterinary practice it is mixed with Zolazolam, a potent anaesthetic at a 1:1 ratio. TS

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is an arylcyclohexylamine chemically related to ketamine.[1][2] WP

It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs. It is sometimes used in combination with xylazine (Rompun) to chemically immobilize large mammals such as polar bears and wood bison. Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.[3–7] WP

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Pharmacology

Pharmacology

Tiletamine acts as an NMDA receptor antagonist at the PCP₁ site, blocking the flow of ions. It acts at this site with a Kᵢ of 55-83 nM, suggesting that it is 6-8x more potent than ketamine there. Compared to other NMDA receptor antagonists such as dizocilpine, PCP, and ketamine, tiletamine does not significantly impact the release or metabolism of dopamine.[13][14] WP

Chemistry

Formula
C12H17NOS PC
CAS number
14176-49-9 PC
Molar mass (g/mol)
223.34 PC
IUPAC name (computed by PubChem)
2-(ethylamino)-2-thiophen-2-ylcyclohexan-1-one PC
SMILES
CCNC1(CCCCC1=O)C2=CC=CS2 PC
InChIKey
QAXBVGVYDCAVLV-UHFFFAOYSA-N PC
PubChem CID
26533

User reports

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Pop culture

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References

  1. Journal / agency Klockgether T, Turski L, Schwarz M, Sontag KH, Lehmann J. Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine. Brain Research. October 1988. doi:10.1016/0006-8993(88)90265-X · PMID 2846121
  2. Other PubChem 26533
  3. Other Tiletamine
  4. Journal / agency Lin HC, Thurmon JC, Benson GJ, Tranquilli WJ. Telazol--a review of its pharmacology and use in veterinary medicine. Journal of Veterinary Pharmacology and Therapeutics. December 1993. doi:10.1111/j.1365-2885.1993.tb00206.x · PMID 8126757
  5. Journal / agency Tiletamine. 21 January 2009
  6. Journal / agency Cattet MR, Caulkett NA, Lunn NJ. Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine. Journal of Wildlife Diseases. July 2003. doi:10.7589/0090-3558-39.3.655 · PMID 14567228
  7. Journal / agency Caulkett NA, Cattet MR, Cantwell S, Cool N, Olsen W. Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations. The Canadian Veterinary Journal = la Revue Veterinaire Canadienne. January 2000. doi:10.4141/cjas61-007 · PMID 10642872 · PMC1476335
  8. Journal / agency Quail MT, Weimersheimer P, Woolf AD, Magnani B. Abuse of telazol: an animal tranquilizer. Journal of Toxicology. Clinical Toxicology. 2001. doi:10.1081/clt-100105161 · PMID 11527235
  9. Journal / agency de la Peña JB, Lee HC, de la Peña IC, Woo TS, Yoon SY, Lee HL, Han JS, Lee JI, Cho YJ, Shin CY, Cheong JH. Rewarding and reinforcing effects of the NMDA receptor antagonist-benzodiazepine combination, Zoletil®: difference between acute and repeated exposure. Behavioural Brain Research. August 2012. doi:10.1016/j.bbr.2012.05.038 · PMID 22659394
  10. Other Lists of: Scheduling Actions, Controlled Substances, Regulated Chemicals
  11. Harm reduction site Schedules of Controlled Substances: Placement of Preparations Which Contain Both Tiletamine and Zolazepam into Schedule III. January 21, 1987
  12. Journal / agency Zhou B, Yang S, Zhou X, Chen Q, Tu E, Zhang B, Shi L, Zhou X. Severe tremors induced by tiletamine e-cigarette and alcohol use: a case report. Frontiers in Psychiatry. 2025. doi:10.3389/fpsyt.2025.1537822 · PMID 40248598 · PMC12004490
  13. Journal / agency Egunlusi AO, Joubert J. NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders. Pharmaceuticals. May 2024. doi:10.3390/ph17050639 · PMID 38794209 · PMC11124131
  14. Journal / agency Popik P, Hołuj M, Kos T, Nowak G, Librowski T, Sałat K. Comparison of the Psychopharmacological Effects of Tiletamine and Ketamine in Rodents. Neurotoxicity Research. November 2017. doi:10.1007/s12640-017-9759-0 · PMID 28577066 · PMC5602060

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.