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Compound

Umeclidinium bromide

Original Wikipedia articleen.wikipedia.org/wiki/Umeclidinium_bromide revision used (24 October 2026)

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Part of the metabolic pathway of Umeclidinium bromide. See the timeline on the metabolic highway.

Enzymes that break it down: CYP2D6. Wikipedia’s drug infobox says: “Liver (CYP2D6)” (revision 1329521167).

Overview

Umeclidinium bromide, sold under the brand name Incruse Ellipta among others, is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD). It is also approved for this indication in combination with vilanterol (as umeclidinium bromide/vilanterol), and also as a triple-therapy combination as fluticasone furoate/umeclidinium bromide/vilanterol.[1–5] WP

It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 245th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[6][7][8] WP

Chemistry

Formula
C29H34BrNO2 PC
CAS number
869113-09-7 PC
Molar mass (g/mol)
508.5 PC
IUPAC name (computed by PubChem)
diphenyl-[1-(2-phenylmethoxyethyl)-1-azoniabicyclo[2.2.2]octan-4-yl]methanol bromide PC
SMILES
C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5.[Br-] PC
InChIKey
PEJHHXHHNGORMP-UHFFFAOYSA-M PC
PubChem CID
11519069

Harm reduction information

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Sources

  1. Journal / agency Incruse Ellipta- umeclidinium aerosol, powder. 13 December 2023
  2. Journal / agency Anoro Ellipta- umeclidinium bromide and vilanterol trifenatate powder. 2 June 2023
  3. Journal / agency Feldman GJ, Edin A. The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects. Therapeutic Advances in Respiratory Disease. December 2013. doi:10.1177/1753465813499789 · PMID 24004659
  4. Other FDA Approves Umeclidinium and Vilanterol Combo for COPD. December 18, 2013
  5. Journal / agency Trelegy Ellipta- fluticasone furoate, umeclidinium bromide and vilanterol trifenatate powder. 2 June 2023
  6. Other World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). 2021
  7. Other The Top 300 of 2020
  8. Other Umeclidinium - Drug Usage Statistics

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.