Compound

Tofenacin

Also called Demethylorphenadrine, Nororphenadrine, Elamol

Original Wikipedia articleen.wikipedia.org/wiki/Tofenacin revision used (24 October 2026)

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Part of the metabolic pathway of Orphenadrine. See the timeline on the metabolic highway.

Overview

Tofenacin is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the United Kingdom and Italy in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part of Astellas Pharma). It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.[1–6] WP

Chemistry

Formula: C17H21NO PC
CAS number: 15301-93-6 PC
Molar mass (g/mol): 255.35 PC
IUPAC name (computed by PubChem): N-methyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine PC
SMILES: CC1=CC=CC=C1C(C2=CC=CC=C2)OCCNC PC
InChIKey: PNYKGCPSFKLFKA-UHFFFAOYSA-N PC
PubChem CID: 25315

Harm reduction information

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Sources

Other Index Nominum 2000: International Drug Directory. 2000
Other Buckingham J. Dictionary of organic compounds: Chemical Abstracts Service registry number index. 1996
Other Pharmaceutical Manufacturing Encyclopedia. 2013-01-15
Other van Dijk J, Hartog J, Hillen FC. Progress in Medicinal Chemistry. 1 January 1978
Journal / agency Capstick N, Pudney H. A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy. The Journal of International Medical Research. 1976. doi:10.1177/030006057600400610 · PMID 800383
Journal / agency Altamura AC, Mauri MC, De Novellis F, Percudani M, Vampini V. Residual neuroleptic-induced parkinsonian symptoms in schizophrenia. A naturalistic study with orphenadrine. Pharmacopsychiatry. November 1989. doi:10.1055/s-2007-1014608 · PMID 2616635

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.