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Orphenadrine

What the body does with Orphenadrine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

OrphenadrinetakenTofenacinmetaboliteExitRenal and biliary

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    90% 1

  2. hoursbreakdown

    Metabolism

    Hepatic demethylation 1

  3. hoursfrom the article text

    What else it turns into

    “Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.” 2

  4. half-lifehalf gone

    Elimination half-life

    13–20 hours 1

  5. exitleaves the body

    Excretion

    Renal and biliary 1

Sources

  1. Wikipedia, Orphenadrine, drug infobox (revision 1363068383), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.
  2. Wikipedia, Tofenacin, article text (revision 1358096539), CC BY-SA 4.0. Sentences quoted as they appear.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.