Compound

Pholedrine

Also called Isodrine, Pulsotyl, Pressitan

Original Wikipedia articleen.wikipedia.org/wiki/Pholedrine revision used (24 October 2026)

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Part of the metabolic pathway of Methamphetamine and PMMA. See the timeline on the metabolic highway.

Overview

Pholedrine, also known as 4-hydroxy-N-methylamphetamine and sold under the brand names Paredrinol, Pulsotyl, and Veritol among others, is a sympathomimetic drug used in topical eye drops to dilate the pupil. It can be used to diagnose Horner's syndrome.[1][2][3] WP

In 2004, it remained marketed only in Germany.[1] WP

Pharmacology

Pharmacodynamics

Pholedrine is described as a sympathomimetic, antihypotensive, and ephedrine-like agent.[1][4][5] WP

History

Pholedrine was synthesized by 1951.[4] WP

Legal status

Names

Pholedrine is the generic name of the drug and its INN (International Nonproprietary Name), BAN (British Approved Name), and DCF (Dénomination Commune Française), while foledrina is its DCIT (Denominazione Comune Italiana). The drug has been sold under brand names including Pholedrin Liquidum, Pholedrin-Longo-Isis, Presoitan, Veritain, and Veritol among others.[1][4][5] WP

Chemistry

Formula: C10H15NO PC
CAS number: 370-14-9 PC
Molar mass (g/mol): 165.23 PC
IUPAC name (computed by PubChem): 4-[2-(methylamino)propyl]phenol PC
SMILES: CC(CC1=CC=C(C=C1)O)NC PC
InChIKey: SBUQZKJEOOQSBV-UHFFFAOYSA-N PC
PubChem CID: 4655

Harm reduction information

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Sources

Other Schweizerischer Apotheker-Verein. Index Nominum: International Drug Directory. 2004
Journal / agency Pholedrine
Journal / agency Bates AT, Chamberlain S, Champion M, Foley L, Hughes E, Jani B, Mehta H, Smith SE. Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome. Journal of Neurology, Neurosurgery, and Psychiatry. February 1995. doi:10.1136/jnnp.58.2.215 · PMID 7876854 · PMC1073320
Other Elks J. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 2014
Other Morton IK, Hall JM. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 2012

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.