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Methamphetamine

What the body does with Methamphetamine, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

MethamphetaminetakenAmphetaminemetabolitePholedrinemetaboliteN-HydroxymethamphetaminemetaboliteExitPrimarily kidney

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    Oral: 3 hours (peak); Intranasal: <15 minutes; Inhalation: <18 minutes; Intravenous: <15 minutes 1

  2. doseabsorbed

    Bioavailability

    Oral: 67%; Intranasal: 79%; Inhalation: 67–90%; Intravenous: 100% 1

  3. hoursbreakdown

    Metabolism

    CYP2D6 and FMO3 1

  4. hoursmade from it

    Metabolites

    Amphetamine; Pholedrine; N-Hydroxymethamphetamine; Norephedrine 1

  5. half-lifehalf gone

    Elimination half-life

    9–12 hours (range 5–30 hours); irrespective of route 1

  6. durationeffects

    Duration of action

    8–12 hours 1

  7. exitleaves the body

    Excretion

    Primarily kidney 1

Source

  1. Wikipedia, Methamphetamine, drug infobox (revision 1377269838), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.