Prolintane
Also called 1-Phenyl-2-pyrrolidinylpentane, Phenylpyrrolidinylpentan, Phenylpyrrolidinopentane
Dosage
Oral bands as drawn from PsychonautWiki's ranges below. The table is the source of truth.
When sources disagree, both rows are shown as published. Nothing is averaged or merged.
Oral
| Source | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| PsychonautWiki | 5 mg PW | 15–25 mg PW | 25–45 mg PW | 45–60 mg PW | 60 mg+ PW |
| TripSit | 5–10 mg TS | 10–15 TS | 15–30 mg TS | 30–50 mg+ TS | – |
TripSit dose text
TripSit's factsheet also states its doses as text.
Threshold: 5-10mg Light: 10-15 Common: 15-30mg Strong: 30-50mg+ TS
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Duration
Oral, drawn at the midpoint of each PsychonautWiki range.
| Route · source | Onset | Come-up | Peak | Offset | Total | After-effects |
|---|---|---|---|---|---|---|
| Oral · PsychonautWiki | 20–60 minutes PW | 20–40 minutes PW | 2–3 hours PW | 1–2 hours PW | 4–6 hours PW | 2–6 hours PW |
TripSit factsheet
Mixing
For best safety practice, don't mix this drug with other stimulants.
Why: vasoconstriction, heart rate and blood pressure. PsychonautWiki says:
- “... may be dangerous to combine with other stimulants ... as they can increase one's heart rate and blood pressure to dangerous levels.” (PsychonautWiki, dangerous interactions table, "Stimulants" row, revision 148925)
- “Vasoconstriction can be described as a narrowing of the veins and blood vessels which results from a contraction of their muscular wall.” (PsychonautWiki, Vasoconstriction, revision 170337)
- “... it can also occur under the influence of traditional stimulants such as methamphetamine, caffeine, and MDMA.” (PsychonautWiki, Vasoconstriction, revision 170337)
- “Increased blood pressure is most commonly induced under the influence of heavy dosages of vasoconstricting compounds, such as traditional stimulants and stimulating psychedelics.” (PsychonautWiki, Increased blood pressure, revision 152273)
Quotes from PsychonautWiki, CC BY-SA 4.0.
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
Other documented combinations
- Stimulants - Prolintane can be potentially dangerous in combination with other stimulants as it can increase one's heart rate and blood pressure to dangerous levels. PW⚠ PsychonautWiki lists this combination without a danger rating.
- MDMA - The neurotoxic effects of MDMA may be increased when combined with amphetamine and other stimulants. PW⚠ PsychonautWiki lists this combination without a danger rating.
- Cocaine - This combination may increase strain on the heart. PW⚠ PsychonautWiki lists this combination without a danger rating.
PsychonautWiki also lists dangerous combinations shared across a whole group (MAOIs, stimulants) in a table this page does not copy. Read that list on PsychonautWiki.
Risks and toxicity
The toxicity and long-term health effects of recreational prolintane use do not seem to have been studied in any scientific context, and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried prolintane within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). PW
Lethal dosage
The exact lethal dosage of prolintane is unknown, and no formal studies have been carried out in humans. The typical adult therapeutic dose of prolintane has been 10-40mg daily. In therapeutic trials, 20mg prolintant is a mild stimulant equivalent to 100mg caffeine. In a study of fatigued volunteers the administration of 20mg or 40mg prolintane produced similar, but less intense effects than 20mg d-amphetamine. In experimental studies of healthy volunteers, prolintane has little cardiovascular activity following the single dose of 20mg.[7] PW
Tolerance and addiction potential
Unlike some of the other more potent stimulants in its class, the chronic use of prolintane can be considered mildly to moderately addictive with only a moderate potential for abuse and is capable of causing psychological dependence among certain users. PW
When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a potential risk among users of prolintane as it can cause compulsive redosing, although typically to a far lesser degree than the notoriously compulsive cathinone analogs A-PVP and MDPV. PW
Psychosis
User reports indicate that chronic abuse or single overdose exposure of prolintane can potentially lead to psychosis. Psychotic symptoms from prolintane can include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, grandiosity, paranoid delusions, confusion, increased aggression, and irritability. PW
TripSit factsheet
- Avoid
- Other stimulants. TS
Testing
Effects
Overview
1-Phenyl-2-pyrrolidinylpentane (also known as Prolintane, and by the trade names Catovit, Promotil, and Villescon) is a synthetic central nervous system (CNS) stimulant that is structurally similar to the substituted pyrrolidine class of compounds such as MDPV and A-PVP albeit with notably attenuated effects. Prolintane was first synthesized in the 1950s, where it was found primarily to act as as a norepinephrine-dopamine reuptake inhibitor (NDRI) which is thought to confer its stimulant and potential nootropic qualities.[1] PW
A stimulant drug which is a dopamine reuptake inhibitor, related to MDPV and Pyrovalerone. It was first developed in the 1950s, and has seen some light usage in rave culture, though it remains relatively uncommon. Believed to have a relatively forgiving safety profile. TS
Prolintane is a central nervous system (CNS) stimulant and norepinephrine–dopamine reuptake inhibitor (NDRI) of the phenylalkylpyrrolidine family developed in the 1950s. Being an amphetamine derivative, it is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine, and has a similar mechanism of action. Many cases of prolintane abuse have been reported.[2–5] WP
Under the brand name Katovit, prolintane was commercialized by the Spanish pharmaceutical company FHER until 2001. It was most often used by students and workers as a stimulant to provide energy and increase alertness and concentration. Prolintane and substituted prolintane analogs (fluoro and methyl) show DAT and NET inhibition in the low nanomolar range, which is consistent with NDRI psychostimulants such a methylphenidate. In addition 4-substituted analogs have SERT inhibition which correlates with amphetamine SAR such as fenfluramine.[6] WP
History
Legal status
Pharmacology
Chemistry
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References
- Other New tertiary amines and their salts and process for their preparation
- Journal / agency Hollister LE, Gillespie HK. A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers. The Journal of Clinical Pharmacology and the Journal of New Drugs. March–April 1970. doi:10.1177/009127007001000205 · PMID 4392006
- Other New tertiary amines and their salts and process for their preparation
- Journal / agency Nicholson AN, Stone BM, Jones MM. Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline. British Journal of Clinical Pharmacology. November 1980. doi:10.1111/j.1365-2125.1980.tb01790.x · PMID 7437258 · PMC1430138
- Journal / agency Kyle PB, Daley WP. Domestic abuse of the European rave drug prolintane. Journal of Analytical Toxicology. September 2007. doi:10.1093/jat/31.7.415 · PMID 17725890
- Journal / agency Kastner N, Islam MN, Dybek M, Roth E, Heisinger S, Holy M, Jäntsch K, Walther D, Stockner T, Baumann MH, Brandt SD, Wallach J, Sitte HH, Kudlacek O. Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences. The Journal of Biological Chemistry. December 2025. doi:10.1016/j.jbc.2025.110903 · PMID 41197716 · PMC12720098
- Journal / agency Moody, D. E. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Journal of Analytical Toxicology. 1 January 2013. doi:10.1093/jat/bks088
- Other Anlage 1 AMVV
- Other Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien
Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0), Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.