Compound

Pheniramine

Also called Prophenpyridamine, Tripoton, Pyriton

Original Wikipedia articleen.wikipedia.org/wiki/Pheniramine revision used (24 October 2026)

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Part of the metabolic pathway of Pheniramine. See the timeline on the metabolic highway.

Overview

Pheniramine (trade name Avil among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis. WP

It was patented in 1948. Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself.[1] WP

Risks and side effects

Side effects

Pheniramine may cause drowsiness or tachycardia, and over-dosage may lead to sleep disorders. WP⚠ Wikipedia itself has flagged this text: citation needed.

Overdose may lead to seizures, especially in combination with alcohol. WP⚠ Wikipedia itself has flagged this text: citation needed.

People combining with cortisol in the long term should avoid pheniramine as it may decrease levels of adrenaline (epinephrine) which may lead to loss of consciousness. WP⚠ Wikipedia itself has flagged this text: citation needed.

Pheniramine is a deliriant (hallucinogen) in toxic doses. Recreational use of Coricidin for the dissociative (hallucinogenic) effect of its dextromethorphan is hazardous because it also contains chlorpheniramine. WP⚠ Wikipedia itself has flagged this text: citation needed.

Chemistry

Formula: C16H20N2 PC
CAS number: 86-21-5 PC
Molar mass (g/mol): 240.34 PC
IUPAC name (computed by PubChem): N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine PC
SMILES: CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2 PC
InChIKey: IJHNSHDBIRRJRN-UHFFFAOYSA-N PC
PubChem CID: 4761
IUPAC name: N,N-Dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine WP

Harm reduction information

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Pop culture

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Sources

Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.