Phenazolam
Also called Clobromazolam, DM-II-90
Part of the metabolic pathway of Phenazolam. See the timeline on the metabolic highway.
Overview
Clobromazolam (also known as phenazolam, DM-II-90, and BRN 4550445) is a synthetic benzodiazepine derivative. It is structurally related to other triazolobenzodiazepines and is believed to act as a potent sedative and hypnotic through positive allosteric modulation of the GABAA receptor.
The compound was first described in the early 1980s during research into novel anxiolytic and hypnotic agents, but it was never developed or approved for medical use.
Clobromazolam has emerged in the 21st century as a designer drug, being sold online and detected in forensic casework. It was first identified in seized samples by a Swedish laboratory in March 2016.
Due to its high potency and lack of clinical evaluation, its use has been associated with significant safety concerns, including the risk of overdose, dependence, and severe central nervous system depression.[1]
Legal status
Legal status
The legal status of clobromazolam varies internationally. It was classified as a controlled substance in Serbia in May 2019 and in Italy in March 2020.
In the United States, clobromazolam is not explicitly scheduled at the federal level as of now, though it may fall under analogue legislation in certain circumstances.[4]
Chemistry
Harm reduction information
No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.
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Sources
- Journal / agency Polívka Z, Holubek J, Metyš J, Šedivŷ Z, Protiva M. Potential hypnotics and anxiolytics: 8-Chloro-6-(2-chlorophenyl)-1-[4-(2-methoxyethyl) piperazino]-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine and related compounds. Collection of Czechoslovak Chemical Communications. 1983. doi:10.1135/cccc19833433
- Other Novel benzodiazepines: A review of the evidence of use and harms. April 2020
- Journal / agency Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR. Flubromazolam-derived designer benzodiazepines: Toxicokinetics and analytical toxicology of clobromazolam and bromazolam. Journal of Analytical Toxicology. October 2020. doi:10.1093/jat/bkaa161 · PMID 33048135
- Other Rulebook on determining the List of psychoactive controlled substances
- Other Ministerial decree. 13 March 2020
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