Compound

Parecoxib

Also called Xapit, Rayzon

Original Wikipedia articleen.wikipedia.org/wiki/Parecoxib revision used (24 October 2026)

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Part of the metabolic pathway of Parecoxib. See the timeline on the metabolic highway.

Enzymes that break it down: CYP3A4. Wikipedia’s drug infobox says: “Liver to valdecoxib and propionic acid; CYP extensively involved (mainly CYP3A4 and 2C9)” (revision 1370867901).

Overview

Parecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved in the European Union for short term perioperative pain control. WP

It was patented in 1996 and approved for medical use in 2002.[1] WP

Chemistry

Formula: C19H18N2O4S PC
CAS number: 198470-84-7 PC
Molar mass (g/mol): 370.4 PC
IUPAC name (computed by PubChem): N-[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)phenyl]sulfonylpropanamide PC
SMILES: CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C PC
InChIKey: TZRHLKRLEZJVIJ-UHFFFAOYSA-N PC
PubChem CID: 119828

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Sources

Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.