intoxicant.wiki2catechol4school
← All metabolic timelinesMetabolic highway

Parecoxib

What the body does with Parecoxib, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

ParecoxibtakenExitKidney (70%, metabolites)

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. doseabsorbed

    Bioavailability

    100% 1

  2. hoursbreakdown

    Metabolism

    Liver to valdecoxib and propionic acid; CYP extensively involved (mainly CYP3A4 and 2C9) 1

  3. half-lifehalf gone

    Elimination half-life

    22 minutes (parecoxib); 8 hours (valdecoxib) 1

  4. exitleaves the body

    Excretion

    Kidney (70%, metabolites) 1

Source

  1. Wikipedia, Parecoxib, drug infobox (revision 1370867901), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.