Onternabez

Overview

Onternabez (also known as HU-308, HU308, PPP-003, and ARDS-003) is a synthetic cannabinoid that acts as a potent cannabinoid agonist. It is highly selective for the cannabinoid-2 receptor (CB₂ receptor) subtype, with a selectivity more than 5,000 times greater for the CB₂ receptor than the CB₁ receptor. The synthesis and characterization of onternabez took place in the laboratory of Raphael Mechoulam at the Hebrew University of Jerusalem (the HU in HU-308) in the late 1990s. The pinene dimethoxy-DMH-CBD derivative onternabez was identified as a potent peripheral CB₂-selective agonist in in vitro and animal studies in 1990 and 1999.[1][2][3] WP⚠ A word may be missing here. It reads this way in the source too.

Drug class

CB2 receptor agonist WP

From the Wikipedia article's infobox.

Legal status

Legal status

Onternabez is non-psychoactive and not scheduled at the federal level in the United States. It is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess there.[4][5] WP

Chemistry

Formula

C27H42O3 PC

CAS number

256934-39-1 PC

Molar mass (g/mol)

414.6 PC

IUPAC name (computed by PubChem)

[(1S,4S,5S)-4-[2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl]-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methanol PC

SMILES

CCCCCCC(C)(C)C1=CC(=C(C(=C1)OC)[C@H]2C=C([C@H]3C[C@@H]2C3(C)C)CO)OC PC

InChIKey

CFMRIVODIXTERW-BDTNDASRSA-N PC

PubChem CID

11553430

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

User reports

Pop culture

No references added yet.

Sources

1. Journal / agency Mechoulam R, Lander N, Breuer A, Zahalka J. Synthesis of the individual, pharmacologically distinct enantiomers of a tetrahydrocannabinol derivative. Tetrahedron Asymmetry. 1990-04-11. doi:10.1016/S0957-4166(00)86322-3
2. Journal / agency Hanus L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M, Pertwee RG, Ross RA, Mechoulam R, Fride E. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proceedings of the National Academy of Sciences of the United States of America. December 1999. doi:10.1073/pnas.96.25.14228 · PMID 10588688 · PMC24419
3. Other Properties of HU-308 ~ Formula C27H42O3
4. Other 21 CFR — Schedules of controlled substances §1308.11 Schedule I
5. Other Chapter 893 - Drug abuse prevention and control

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.