Compound

Ombitasvir

Original Wikipedia articleen.wikipedia.org/wiki/Ombitasvir revision used (24 October 2026)

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Part of the metabolic pathway of Ombitasvir. See the timeline on the metabolic highway.

Overview

Ombitasvir is an antiviral drug for the treatment of hepatitis C virus (HCV) infection by AbbVie. In the United States, it is approved by the Food and Drug Administration for use in combination with paritaprevir, ritonavir and dasabuvir in the product Viekira Pak for the treatment of HCV genotype 1, and with paritaprevir and ritonavir in the product Technivie for the treatment of HCV genotype 4.[1–4] WP

Ombitasvir is an NS5A inhibitor that acts by inhibiting the HCV protein NS5A.[5] WP

Chemistry

Formula: C50H67N7O8 PC
CAS number: 1258226-87-7 PC
Molar mass (g/mol): 894.1 PC
IUPAC name (computed by PubChem): methyl N-[(2S)-1-[(2S)-2-[[4-[(2S,5S)-1-(4-tert-butylphenyl)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate PC
SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)NC2=CC=C(C=C2)[C@@H]3CC[C@H](N3C4=CC=C(C=C4)C(C)(C)C)C5=CC=C(C=C5)NC(=O)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC PC
InChIKey: PIDFDZJZLOTZTM-KHVQSSSXSA-N PC
PubChem CID: 54767916

Harm reduction information

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Sources

Other VIEKIRA PAK™ (ombitasvir, paritaprevir and ritonavir tablets; dasabuvir tablets), for Oral Use. Full Prescribing Information
Journal / agency FDA approves Viekira Pak to treat hepatitis C. December 19, 2014
Other TECHNIVIE™ (ombitasvir, paritaprevir and ritonavir) Tablets, for Oral Use. Full Prescribing Information
Journal / agency FDA approves Technivie for treatment of chronic hepatitis C genotype 4. July 24, 2015
Journal / agency Feld JJ, Kowdley KV, Coakley E, Sigal S, Nelson DR, Crawford D, Weiland O, Aguilar H, Xiong J, Pilot-Matias T, DaSilva-Tillmann B, Larsen L, Podsadecki T, Bernstein B. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. The New England Journal of Medicine. April 2014. doi:10.1056/NEJMoa1315722 · PMID 24720703

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.