Paritaprevir
Part of the metabolic pathway of Paritaprevir. See the timeline on the metabolic highway.
Enzymes that break it down: CYP3A4 and CYP3A5. Wikipedia’s drug infobox says: “Hepatic, CYP3A4 and CYP3A5” (revision 1259356335).
Overview
Paritaprevir (previously known as ABT-450) is an acylsulfonamide inhibitor of the NS3-4A serine protease manufactured by Abbott Laboratories that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1. Resistance to treatment with paritaprevir is uncommon, because it targets the binding site, but has been seen to arise due to mutations at positions 155 and 168 in NS3.[1–5] WP
Paritaprevir was a component of Viekira Pak and Technivie. In May 2018, the FDA announced that Technivie and Viekira were to be discontinued. The discontinuation was voluntary and not related to the safety, quality, or efficacy of the medicine. It was estimated that both medications would be available until January 1, 2019.[6]
Chemistry
- Formula
- C40H43N7O7S PC
- CAS number
- 1216941-48-8 PC
- Molar mass (g/mol)
- 765.9 PC
- IUPAC name (computed by PubChem)
- (1S,
4R, PC6S, 7Z, 14S, 18R) - N- cyclopropylsulfonyl- 14- [(5- methylpyrazine- 2- carbonyl) amino] - 2, 15- dioxo- 18- phenanthridin- 6- yloxy- 3, 16- diazatricyclo[14.3.0.04, 6] nonadec- 7- ene- 4- carboxamide - SMILES
- CC1=CN=C(C=N1)
C(=O) PCN[C@H] 2CCCCC/C=C\[C@@H] 3C[C@] 3(NC(=O) [C@@H] 4C[C@H] (CN4C2=O) OC5=NC6=CC=CC=C6C7=CC=CC=C75) C(=O) NS(=O) (=O) C8CC8 - InChIKey
- UAUIUKWPKRJZJV-
QPLHLKROSA- PCN - PubChem CID
- 45110509
Harm reduction information
No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.
User reports
Erowid erowid.org
ListingsBluelight bluelight.org
ListingsReddit reddit.com
ListingsPop culture
No references added yet.
Add a reference
Registered users can add songs, films, books, shows, games and art about this substance. Link a source that names the substance, such as the work's Wikipedia article, a review or an interview, not only the work itself. Entries are voted on and moderated like every other value on this page.
Opens when accounts launch.
Sources
- Other Hepatitis C: antiviral drug discovery and development. 2011
- Other Hepatitis C. 2013
- Other Abbott Announces Phase 3 Hepatitis C Program Details
- Journal / agency Kowdley KV, Lawitz E, Poordad F, Cohen DE, Nelson DR, Zeuzem S, Everson GT, Kwo P, Foster GR, Sulkowski MS, Xie W, Pilot-Matias T, Liossis G, Larsen L, Khatri A, Podsadecki T, Bernstein B. Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. The New England Journal of Medicine. January 2014. doi:10.1056/NEJMoa1306227 · PMID 24428468
- Other Lange C, Sarrazin C. Hepatology 2013 a clinical textbook. 2013
- Other TECHNIVIE™ (ombitasvir, paritaprevir and ritonavir) Tablets, for Oral Use. Full Prescribing Information
- Journal / agency Current and Resolved Drug Shortages and Discontinuations Reported to FDA
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.