Norflurazepam
Also called N-Desalkylflurazepam, Norfludiazepam, Descarbethoxyloflazepate, Norflutoprazepam
Part of the metabolic pathway of Flurazepam and Norflurazepam. See the timeline on the metabolic highway.
Dosage
Oral
TripSit dose text
TripSit's factsheet also states its doses as text.
Light: 2-5mg Common: 5-10mg Strong: 10-20mg+ TS
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Duration
TripSit factsheet
Mixing
For best safety practice, don't mix this drug with other depressants.
Why: respiratory depression. PsychonautWiki says:
- “Respiratory depression (also known as hypoventilation) can be described as a reduced urge to breathe that can be fatal depending on its intensity.” (PsychonautWiki, Respiratory depression, revision 150612)
- “... otherwise safe dosages of these compounds can become fatal when combined with even small amounts of other classes of depressant. For example, benzodiazepines combined with opioids are an extremely common cause of fatal respiratory depression. It is therefore strongly discouraged to combine these depressants at any dosage range.” (PsychonautWiki, Respiratory depression, revision 150612)
- “The most common cause of substance-related deaths is the combination of depressants (such as opiates, benzodiazepines, or alcohol) with other depressants.” (PsychonautWiki, Responsible drug use, revision 168206)
- “This combination potentiates the muscle relaxation, amnesia, sedation, and respiratory depression caused by one another. At higher doses, it can lead to a sudden, unexpected loss of consciousness along with a dangerous amount of depressed respiration.” (PsychonautWiki, dangerous interactions table, "Depressants" row, revision 156847)
Quotes from PsychonautWiki, CC BY-SA 4.0.
Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.
Backed by medical journals
TripSit combination chart
TripSit rates each pairing. Only pairings with a number carry a citation from TripSit. See the whole chart; TripSit's own notes are on combo.tripsit.me.
Caution
Risks and toxicity
TripSit factsheet
- Avoid
- All other CNS depressants. TS
Testing
Effects
Overview
Benzodiazepine analogue that is an active metabolite to many other benzodiazepines, such as Flurazepam, Flutoprazepam, and Midazolam. TS
N-Desalkylflurazepam (also known as norflurazepam) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.[1–10] WP
History
Legal status
Pharmacology
Pharmacokinetics
N-Desalkylflurazepam has an elimination half-life of 47–150 hours (up to 200 hours in some healthy volunteers), with an average of ~71 hours. Peak blood concentrations of N-Desalkylflurazepam is reached at 10.2 h following a single 15 mg dose of Flurazepam, typically around ~10-20.4 ng/mL.[9]
Its plasma levels are unreliable amongst patients, and are largely influenced by liver disease, liver enzyme inducers and inhibitors, as well as old age (in men).[9] WP
Chemistry
- Formula
- C15H10ClFN2O PC
- CAS number
- 2886-65-9 PC
- Molar mass (g/mol)
- 288.70 PC
- IUPAC name (computed by PubChem)
- 7-
chloro- PC5- (2- fluorophenyl) - 1, 3- dihydro- 1, 4- benzodiazepin- 2- one - SMILES
- C1C(=O)
NC2=C(C=C(C=C2) PCCl) C(=N1) C3=CC=CC=C3F - InChIKey
- UVCOILFBWYKHHB-
UHFFFAOYSA- PCN - PubChem CID
- 4540
- IUPAC name
- 7-
Chloro- WP5- (2- fluorophenyl) - 1, 3- dihydro- 1, 4- benzodiazepin- 2- one
User reports
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ListingsPop culture
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References
- Journal / agency Riva R, de Anna M, Albani F, Baruzzi A. Rapid quantitation of flurazepam and its major metabolite, N-desalkylflurazepam, in human plasma by gas-liquid chromatography with electron-capture detection. Journal of Chromatography. March 1981. doi:10.1016/S0378-4347(00)84153-5 · PMID 7228960
- Journal / agency Barzaghi N, Leone L, Monteleone M, Tomasini G, Perucca E. Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects. European Journal of Drug Metabolism and Pharmacokinetics. 1989. doi:10.1007/bf03190114 · PMID 2633923
- Other Human Toxicology. December 1996
- Journal / agency Vogt S, Kempf J, Buttler J, Auwärter V, Weinmann W. Desalkylflurazepam found in patients' samples after high-dose midazolam treatment. Drug Testing and Analysis. 2013. doi:10.1002/dta.1484 · PMID 23713025
- Journal / agency Miyaguchi H, Kuwayama K, Tsujikawa K, Kanamori T, Iwata YT, Inoue H, Kishi T. A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry. Forensic Science International. February 2006. doi:10.1016/j.forsciint.2005.03.011 · PMID 15869852
- Journal / agency Nikaido AM, Ellinwood EH. Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance. Psychopharmacology. 1987. doi:10.1007/bf00176478 · PMID 2888152
- Journal / agency Ba BB, Iliadis A, Cano JP. Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites. Annals of Biomedical Engineering. 1989. doi:10.1007/bf02367467 · PMID 2574017
- Journal / agency Davi H, Guyonnet J, Necciari J, Cautreels W. Determination of circulating ethyl loflazepate metabolites in the baboon by radio-high-performance liquid chromatography with injection of crude plasma samples: comparison with solvent extraction and thin-layer chromatography. Journal of Chromatography. July 1985. doi:10.1016/S0378-4347(00)84498-9 · PMID 2864352
- Journal / agency Greenblatt DJ, Abernethy DR, Divoll M, Harmatz JS, Shader RI. Pharmacokinetic properties of benzodiazepine hypnotics. Journal of Clinical Psychopharmacology. April 1983. doi:10.1097/00004714-198304000-00036 · PMID 6132931
- Journal / agency Manchester KR, Maskell PD, Waters L. Experimental versus theoretical log D7.4, pKₐ and plasma protein binding values for benzodiazepines appearing as new psychoactive substances. Drug Testing and Analysis. March 2018. doi:10.1002/dta.2387 · PMID 29582576
- Other Flurazepam. Accessed 31 August 2025 Drugs.com monograph flurazepam
- Journal / agency Nikfarjam Z, Doustkhahb E, Zamanic F, Brownd RW. Benzodiazepine-Based Drug Discovery. August 2022. doi:10.1016/B978-0-12-824516-3.00009-4
Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), TripSit factsheets, PubChem (public domain). Each value links to the exact revision it came from.