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Fentanyl

What the body does with Fentanyl, from the dose to the exit, as its Wikipedia drug infobox records it.

Quoted from the Wikipedia infobox, not yet written up by hand. The order is the usual order of events, not a measured schedule.

FentanyltakenExitMostly urinary (metabolites, < 10% uncha

The clock, on a log scale

Each bar runs from the dose to about five half-lives, roughly when 97% of that molecule has been converted or cleared. The scale is logarithmic so minutes and days fit on one line.

  1. 0 → onsetdose

    Onset

    5 minutes 1

  2. doseabsorbed

    Bioavailability

    Transdermal: 90–92%; Intranasal: 89%; Buccal: 51% (tablets), 71% (film); Sublingual: 54% (Abstral tablets), 76% (spray); Oral: 35%; Inhalation: 56–96%; IM & IV: 100% 1

  3. hoursbreakdown

    Metabolism

    Liver, primarily by CYP3A4; Norfentanyl; Despropionylfentanyl (minor); Hydroxyfentanyl (minor); Hydroxynorfentanyl (minor secondary metabolite) 1

  4. half-lifehalf gone

    Elimination half-life

    IV: 6 mins (T1/2 α); 1 hours (T1/2 β); 16 hours (T1/2 ɣ); Intranasal: 15–25 hours; Transdermal: 20–27 hours; Sublingual: 5–13.5 hours; Buccal: 3.2–6.4 hours 1

  5. durationeffects

    Duration of action

    IV: 30–60 minutes 1

  6. exitleaves the body

    Excretion

    Mostly urinary (metabolites, < 10% unchanged drug) 1

Source

  1. Wikipedia, Fentanyl, drug infobox (revision 1376528965), CC BY-SA 4.0. Values quoted as they appear, with wiki markup removed.

Half-lives vary between people, doses and routes. This page explains what the body does with a drug. It is not dosing advice.