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Compound

Norfentanyl

Original Wikipedia articleen.wikipedia.org/wiki/Norfentanyl revision used (24 October 2026)

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Overview

Norfentanyl is an inactive synthetic opioid analgesic drug precursor. It is an analog and metabolite of fentanyl with the removal of the phenethyl moiety (or functional group) from fentanyl chemical structure.[1–9] WP

Chemistry

Formula
C14H20N2O PC
CAS number
1609-66-1 PC
Molar mass (g/mol)
232.32 PC
IUPAC name (computed by PubChem)
N-phenyl-N-piperidin-4-ylpropanamide PC
SMILES
CCC(=O)N(C1CCNCC1)C2=CC=CC=C2 PC
InChIKey
PMCBDBWCQQBSRJ-UHFFFAOYSA-N PC
PubChem CID
259381

Harm reduction information

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Sources

  1. Journal / agency Fentanyl
  2. Journal / agency Sofalvi, Szabolcs. An LC–MS-MS method for the analysis of carfentanil, 3-methylfentanyl, 2-furanyl fentanyl, acetyl fentanyl, fentanyl and norfentanyl in postmortem and impaired-driving cases. Journal of Analytical Toxicology. 2017. doi:10.1093/jat/bkx052 · PMID 28830122
  3. Journal / agency Bista, Sudeep R. Development, validation and application of an HPLC–MS/MS method for the determination of fentanyl and nor-fentanyl in human plasma and saliva. Journal of Chromatography. 2014
  4. Journal / agency Huynh, N-H. Determination of fentanyl in human plasma and fentanyl and norfentanyl in human urine using LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 2005. doi:10.1016/j.jpba.2004.09.024 · PMID 15862690
  5. Journal / agency Poklis, Alphonse. Urine concentrations of fentanyl and norfentanyl during application of Duragesic® transdermal patches. Journal of Analytical Toxicology. 2004. doi:10.1093/jat/28.6.422 · PMID 15516290
  6. Journal / agency Coopman, Vera. LC–MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic® transdermal therapeutic systems. Forensic Science International. 2007. doi:10.1016/j.forsciint.2006.03.018 · PMID 16650707
  7. Journal / agency Peer, Cody J. Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases. Journal of Analytical Toxicology. 2007. doi:10.1093/jat/31.8.515 · PMID 17988466
  8. Journal / agency Vandergrift, Gregory W. Paper spray mass spectrometry for the direct, semi-quantitative measurement of fentanyl and norfentanyl in complex matrices. Clinical Biochemistry. 2018. doi:10.1016/j.clinbiochem.2018.02.005 · PMID 29432758
  9. Journal / agency Patton, Amy L. Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS. Analytical Chemistry. 2014. doi:10.1021/ac4036197 · PMID 24354295

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