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Adenosine receptor agonist · Sedative · Hypnotic

YZG-331

Also called N6-[(S)-1-(phenyl)-propyl]-adenosine

Original Wikipedia articleen.wikipedia.org/wiki/YZG-331 revision used (24 October 2026)

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Overview

YZG-331, also known as N⁶-[(S)-1-(phenyl)propyl]adenosine, is an adenosine receptor agonist which is or was under investigation for the potential treatment of insomnia.[1][2][3] WP

Drug class

Adenosine receptor agonist Sedative Hypnotic WP

From the Wikipedia article's infobox.

Pharmacology

Pharmacology

The drug appears to act through the adenosine A₁ and A2A receptors. It produces sedative and hypnotic effects and hypolocomotion in animals. The drug is orally active and crosses the blood–brain barrier, although its intestinal absorption and central permeability may be reduced by its P-glycoprotein substrate activity. It is a synthetic derivative of adenosine and of N⁶-(4-hydroxybenzyl)adenine riboside (NHBA). The latter compound is found in the traditional Chinese medicinal herb Gastrodia elata.[3][4][5] WP

Chemistry

Formula
C19H23N5O4 PC
Molar mass (g/mol)
385.4 PC
IUPAC name (computed by PubChem)
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(1S)-1-phenylpropyl]amino]purin-9-yl]oxolane-3,4-diol PC
SMILES
CC[C@@H](C1=CC=CC=C1)NC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O PC
InChIKey
RRRLUFHDFDNPMZ-BPAMBQHCSA-N PC
PubChem CID
54282370

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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Sources

  1. Other Delving into the Latest Updates on YZG-331 with Synapse. 8 May 2025
  2. Journal / agency Atkin T, Comai S, Gobbi G. Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery. Pharmacological Reviews. April 2018. doi:10.1124/pr.117.014381 · PMID 29487083
  3. Journal / agency Tang B, Yu Y, Yu F, Fang J, Wang G, Jiang J, Han Q, Shi J, Zhang J. The mechanism study of YZG-331 on sedative and hypnotic effects. Behavioural Brain Research. June 2022. doi:10.1016/j.bbr.2022.113885 · PMID 35398229
  4. Journal / agency Chaturvedi S, Rashid M, Malik MY, Agarwal A, Singh SK, Gayen JR, Wahajuddin M. Neuropharmacokinetics: a bridging tool between CNS drug development and therapeutic outcome. Drug Discovery Today. May 2019. doi:10.1016/j.drudis.2019.02.007 · PMID 30898661
  5. Journal / agency Liu Z, Mi J, Yang S, Zhao M, Li Y, Sheng L. Effects of P-glycoprotein on the intestine and blood-brain barrier transport of YZG-331, a promising sedative-hypnotic compound. European Journal of Pharmacology. November 2016. doi:10.1016/j.ejphar.2016.08.039 · PMID 27612629

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.