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Stimulant (Weak)

Tyrosine

Also called L-Tyrosine, 4-Hydroxyphenylalanine, p-Tyrosine, L-p-Tyrosine, 4-Hydroxy-L-phenylalanine

Original Wikipedia articleNot linked yet. It gets linked once the exact article is confirmed.
Common dose · Oral1000–2000 mg PW
Onset30–90 minutes PW
Total2–4 hours PW
After-effects6–12 hours PW

Dosage

Oral

SourceThresholdLightCommonStrongHeavy
PsychonautWiki300 mg PW500–1000 mg PW1000–2000 mg PW2000–3000 mg PW3000 mg+ PW
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Duration

Route · sourceOnsetCome-upPeakOffsetTotalAfter-effects
Oral · PsychonautWiki30–90 minutes PW–1–3 hours PW–2–4 hours PW6–12 hours PW

Mixing

For best safety practice, don't mix this drug with other stimulants.

Why: vasoconstriction, heart rate and blood pressure. PsychonautWiki says:

Quotes from PsychonautWiki, CC BY-SA 4.0.

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Awaiting sourcePeer-reviewed reports on acute combinations, from PubMed and the journals the harm reduction sites cite.

Other documented combinations

  • Stimulants - Tyrosine is stimulatory on its own. Therefore, it may theoretically interact with other stimulatory pharmaceuticals or supplements and cause dangerously high blood pressure or heartrate. PW⚠ PsychonautWiki lists this combination without a danger rating.
  • MDMA - The neurotoxic effects of MDMA may be increased when combined with amphetamine and other stimulants. PW⚠ PsychonautWiki lists this combination without a danger rating.
  • Cocaine - This combination may increase strain on the heart. PW⚠ PsychonautWiki lists this combination without a danger rating.

PsychonautWiki also lists dangerous combinations shared across a whole group (MAOIs, stimulants) in a table this page does not copy. Read that list on PsychonautWiki.

Risks and toxicity

Tyrosine is physically safe, is not known to cause brain damage, and has an extremely low toxicity relative to dose. Similar to many other nootropic drugs, there are relatively few physical side effects associated with acute tyrosine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort. However, it is still strongly recommended that one use harm reduction practices when using this drug. PW

Tolerance and addiction potential

Tyrosine may potentially be mildly habit forming and the desire to use it may actually increase with use. This is because of its dopaminergic properties. However, in comparison to other more traditional stimulants such as amphetamine or methylphenidate, it is not nearly as addictive or compulsive. PW

Tolerance to the effects of tyrosine are quickly built after repeated and frequent usage. After that, it takes about 7 days for the tolerance to be reduced to half and 14 days to be back at baseline (in the absence of further consumption). Tyrosine presents cross-tolerance with other dopaminergic stimulants, meaning that after the consumption of tyrosine, most other stimulant compounds will have a reduced effect. PW

Testing

Awaiting sourceReagent reactions and test kit guidance from a harm reduction testing service.

Effects

Awaiting sourceSubjective and physical effects from PsychonautWiki or TripSit.

Overview

Tyrosine (also known as L-Tyrosine and 4-hydroxyphenylalanine) is a non-essential amino acid that serves a precursor to dopamine, adrenaline and norepinephrine in the human body. As a supplement, it is reported to act as a mild stimulant. It is also one of the 22 amino acids that are used by cells to synthesize proteins and is abundant in many high-protein foods, such as chicken, turkey, fish, cottage cheese, cheese, yogurt, almonds, milk, avocados, bananas, peanuts, pumpkin seeds, sesame seeds and soy products.[1] PW

History

Awaiting sourceHistory and culture from Wikipedia or PsychonautWiki, with their citations.

Pharmacology

Awaiting sourcePharmacology from Wikipedia and the journal papers it cites.

Chemistry

Awaiting sourceFormula, structure and identifiers from PubChem.

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Pop culture

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References

  1. Other Foods highest in Tyrosine

Text and values on this page are quoted from PsychonautWiki (CC BY-SA 4.0). Each value links to the exact revision it came from.