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Compound

Triprolidine

Also called Actidil, Tripolidina, Histafed

Original Wikipedia articleen.wikipedia.org/wiki/Triprolidine revision used (24 October 2026)

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Part of the metabolic pathway of Triprolidine. See the timeline on the metabolic highway.

Enzymes that break it down: CYP2D6. Wikipedia’s drug infobox says: “Hepatic (CYP2D6)” (revision 1354892877).

Overview

Triprolidine is an over-the-counter first-generation antihistamine with strong anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other medications in preparations designed to provide general relief for flu-like symptoms. As with many antihistamines, the most common side effect is drowsiness.[1][2] WP

Triprolidine was patented in 1948 and came into medical use in 1953, and has mostly been replaced in popular cold and flu medications by other drugs such as diphenhydramine, promethazine, chlorpheniramine, loratadine and fexofenadine.[3] WP

Chemistry

Formula
C19H22N2 PC
CAS number
486-12-4 PC
Molar mass (g/mol)
278.4 PC
IUPAC name (computed by PubChem)
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine PC
SMILES
CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3 PC
InChIKey
CBEQULMOCCWAQT-WOJGMQOQSA-N PC
PubChem CID
5282443

Harm reduction information

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Sources

  1. Journal / agency Goldsmith P, Dowd PM. The new H1 antihistamines. Treatment of urticaria and other clinical problems. Dermatologic Clinics. January 1993. doi:10.1016/S0733-8635(18)30285-7 · PMID 8094649
  2. Journal / agency Williams BO, Liao SH, Lai AA, Arnold JD, Perkins JG, Blum MR, Findlay JW. Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products. Clinical Pharmacy. 1984. PMID 6509877
  3. Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.