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Compound

Triclabendazole

Also called Fasinex, Egaten, NVP-EGA230

Original Wikipedia articleen.wikipedia.org/wiki/Triclabendazole revision used (24 October 2026)

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Part of the metabolic pathway of Triclabendazole. See the timeline on the metabolic highway.

Overview

Triclabendazole, sold under the brand name Egaten among others, is a medication used to treat fascioliasis and paragonimiasis. It is very effective for both conditions. Treatment in hospital may be required. It is taken by mouth with typically one or two doses being required.[1] WP

Side effects are generally few, but can include abdominal pain and headaches. Biliary colic may occur due to dying worms. While no harm has been found with use during pregnancy, triclabendazole has not been studied well in this population. It is a member of the benzimidazole family of medications for worms.[1][2] WP

Triclabendazole was approved for medical use in the United States in 2019. It is on the World Health Organization's List of Essential Medicines. For human use, it can be obtained from the World Health Organization. It is also used in animals.[2–6] WP

History

History

Since the late 1990s, triclabendazole has been available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat infections by Fasciola hepatica (both immature and adult liver flukes), roundworms and ectoparasites, as well. WP⚠ Wikipedia itself has flagged this text: citation needed.

Fasinex is a brand name for veterinary use, while Egaten is a brand name for human use. WP⚠ Wikipedia itself has flagged this text: citation needed.

Chemistry

Formula
C14H9Cl3N2OS PC
CAS number
68786-66-3 PC
Molar mass (g/mol)
359.7 PC
IUPAC name (computed by PubChem)
6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzimidazole PC
SMILES
CSC1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl PC
InChIKey
NQPDXQQQCQDHHW-UHFFFAOYSA-N PC
PubChem CID
50248
IUPAC name
5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole WP

Harm reduction information

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Sources

  1. Other World Health Organization. WHO Model Formulary 2008. 2009
  2. Other Wolfe MM, Lowe RC. Pocket Guide to GastrointestinaI Drugs. 2014
  3. Journal / agency Drug Trials Snapshots: Egaten. 13 February 2019
  4. Journal / agency Egaten (triclabendazole)
  5. Other World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. 2019
  6. Other Triclabendazole

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.