intoxicant.wiki2catechol4school
Compound

Tolvaptan phosphate

Original Wikipedia articleen.wikipedia.org/wiki/Tolvaptan_phosphate revision used (24 October 2026)

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Part of the metabolic pathway of Tolvaptan phosphate. See the timeline on the metabolic highway.

Overview

Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan, formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration.[1][2] WP

It was developed by Otsuka Pharmaceutical Co. and was approved for use in Japan in 2022.[3] WP

Chemistry

Formula
C26H26ClN2O6P PC
Molar mass (g/mol)
528.9 PC
IUPAC name (computed by PubChem)
[(5R)-7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1-benzazepin-5-yl] dihydrogen phosphate PC
SMILES
CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCC[C@H](C4=C3C=CC(=C4)Cl)OP(=O)(O)O)C PC
InChIKey
XTCFGVRVASPRTK-XMMPIXPASA-N PC
PubChem CID
146035877

Harm reduction information

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Sources

  1. Journal / agency Kinugawa K, Nakata E, Hirano T, Kim S. Tolerability of the Intravenously Administered Tolvaptan Prodrug, OPC-61815, in Patients With Congestive Heart Failure Who Have Difficulty With, or Are Incapable of, Oral Intake (TRITON-HF) - A Phase III, Multicenter, Open-Label Trial. Circulation Journal. March 2022. doi:10.1253/circj.CJ-21-0926 · PMID 35264514
  2. Journal / agency Sato N, Uno S, Yamasaki Y, Hirano T, Kim S. Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of OPC-61815, a Prodrug of Tolvaptan for Intravenous Administration, in Patients With Congestive Heart Failure - A Phase II, Multicenter, Double-Blind, Randomized, Active-Controlled Trial. Circulation Journal. March 2022. doi:10.1253/circj.CJ-21-0430 · PMID 34511586
  3. Other Otsuka Obtains Approval in Japan for SAMTASU® for I.V. Infusion, a V2 -Receptor Antagonist for the Treatment of Cardiac Edema. March 28, 2022

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.