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Compound

Tinidazole

Also called Fasigyn, Tricolam, Trimonase

Original Wikipedia articleen.wikipedia.org/wiki/Tinidazole revision used (24 October 2026)

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Part of the metabolic pathway of Tinidazole. See the timeline on the metabolic highway.

Enzymes that break it down: CYP3A4. Wikipedia’s drug infobox says: “Liver (CYP3A4)” (revision 1366501484).

Overview

Tinidazole, sold under the brand name Tindamax among others, is a medication used against infections caused by certain anaerobic bacteria and protozoa. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.[1] WP

Tinidazole is a therapeutic alternative on the World Health Organization's List of Essential Medicines.[2] WP

Uses, dosage and effects

Medical uses

Tinidazole is a narrow spectrum antimicrobial drug used to treat infections caused by Helicobacter pylori, Entamoeba histolytica, Giardia spp. and Trichomonas vaginalis.[3] WP

Risks and side effects

Side effects

Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath. WP⚠ Part of this sentence could not be copied from the source. Open the source to read it in full.

Median lethal dose (LD50) in animals

Quoted from PubChem's Non-Human Toxicity Values, which come from the Hazardous Substances Data Bank (HSDB). PubChem describes them as: “Quantitative non-human toxicity values (e.g., lethal dose) for this compound. The data shown here are mostly for lab animals (e.g., rat, mouse, guinea pig, and rabbit).” and defines the “LD50 (median lethal dose, the estimated amount of a chemical expected to kill 50% of test animals in a single dose)”. PC

LD50 (as the source gives it)Reference
LD50 Mouse acute > 3,600 mg/kg PCPhysicians Desk Reference 60th ed, Thomson PDR, Montvale, NJ 2006., p. 2671 (via HSDB record 7362)
LD50 Mouse ip > 2,300 mg/kg PCPhysicians Desk Reference 60th ed, Thomson PDR, Montvale, NJ 2006., p. 2671 (via HSDB record 7362)
LD50 Rat oral > 2,000 mg/kg PCPhysicians Desk Reference 60th ed, Thomson PDR, Montvale, NJ 2006., p. 2671 (via HSDB record 7362)
LD50 Rat ip > 2,000 mg/kg PCPhysicians Desk Reference 60th ed, Thomson PDR, Montvale, NJ 2006., p. 2671 (via HSDB record 7362)

Pharmacology

Pharmacokinetics

Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours. WP⚠ Part of this sentence could not be copied from the source. Open the source to read it in full.

History

History

Tinidazole was approved for medical treatment in the United States in 2004.[4][5] WP

Chemistry

Formula
C8H13N3O4S PC
Molar mass (g/mol)
247.27 PC
IUPAC name (computed by PubChem)
1-(2-ethylsulfonylethyl)-2-methyl-5-nitroimidazole PC
SMILES
CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C PC
InChIKey
HJLSLZFTEKNLFI-UHFFFAOYSA-N PC
PubChem CID
5479
IUPAC name
1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole WP

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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User reports

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Pop culture

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Sources

  1. Journal / agency Ebel K, Koehler H, Gamer AO, Jäckh R. In Ullmann's Encyclopedia of Industrial Chemistry. 2002. doi:10.1002/14356007.a13_661
  2. Other The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. 2025
  3. Journal / agency Edwards DI. Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action. The Journal of Antimicrobial Chemotherapy. January 1993. doi:10.1093/jac/31.1.9 · PMID 8444678
  4. Journal / agency Tindamax- tinidazole tablet, film coated. 27 December 2021
  5. Journal / agency Drug Approval Package: Tindamax (Tinidazole) NDA #021618, 021681 & 021682

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.