intoxicant.wiki2catechol4school
Compound

Tilorone

Also called Bis-DEAE-fluorenone, 2,7-Bis-DEAE-fluorenone, DEAE-F

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Part of the metabolic pathway of Tilorone. See the timeline on the metabolic highway.

Overview

Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer. It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice. It shows activity against Eastern equine encephalitis and related viruses.[1][2][3] WP

Pharmacology

Pharmacology

Tilorone activates the production of interferon.[1] WP

Chemistry

Formula
C25H34N2O3 PC
CAS number
27591-97-5 PC
Molar mass (g/mol)
410.5 PC
IUPAC name (computed by PubChem)
2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one PC
SMILES
CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC PC
InChIKey
MPMFCABZENCRHV-UHFFFAOYSA-N PC
PubChem CID
5475
IUPAC name
2,7-Bis(2-diethylaminoethoxy)fluoren-9-one WP

Harm reduction information

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Sources

  1. Journal / agency Stringfellow DA, Glasgow LA. Tilorone hydrochloride: an oral interferon-inducing agent. Antimicrobial Agents and Chemotherapy. August 1972. doi:10.1128/aac.2.2.73 · PMID 4670490 · PMC444270
  2. Journal / agency Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection. Antimicrobial Agents and Chemotherapy. February 2018. doi:10.1128/AAC.01711-17 · PMID 29133569 · PMC5786809
  3. Journal / agency Ogorek TJ, Golden JE. Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses. Viruses. February 2023. doi:10.3390/v15020413 · PMID 36851628 · PMC9958955

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