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Compound

Tiaprofenic acid

Also called Surgam, Tiaprofen, Suralgan

Original Wikipedia articleen.wikipedia.org/wiki/Tiaprofenic_acid revision used (24 October 2026)

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Part of the metabolic pathway of Tiaprofenic acid. See the timeline on the metabolic highway.

Overview

Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended for children. WP

Long-term use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections. It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and should be used cautiously in renal disease.[1] WP

It was patented in 1969 and approved for medical use in 1981. It is available in generic formulations. A sustained-release preparation is available. It is an isomer of Suprofen.[2] WP

Chemistry

Formula
C14H12O3S PC
CAS number
33005-95-7 PC
Molar mass (g/mol)
260.31 PC
IUPAC name (computed by PubChem)
2-(5-benzoylthiophen-2-yl)propanoic acid PC
SMILES
CC(C1=CC=C(S1)C(=O)C2=CC=CC=C2)C(=O)O PC
InChIKey
GUHPRPJDBZHYCJ-UHFFFAOYSA-N PC
PubChem CID
5468
IUPAC name
(RS)-2-(5-benzoyl-2-thienyl)propanoic acid WP

Harm reduction information

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Sources

  1. Journal / agency Crawford ML, Waller PC, Wood SM. Severe cystitis associated with tiaprofenic acid. British Journal of Urology. 1997. doi:10.1046/j.1464-410X.1997.00094.x · PMID 9126086
  2. Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.