intoxicant.wiki2catechol4school
Compound

Tegaserod

Original Wikipedia articleen.wikipedia.org/wiki/Tegaserod revision used (24 October 2026)

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Part of the metabolic pathway of Tegaserod. See the timeline on the metabolic highway.

Overview

Tegaserod is a 5-HT₄ agonist manufactured by Novartis and sold under the names Zelnorm and Zelmac for the management of irritable bowel syndrome and constipation. Approved by the FDA in 2002, it was subsequently removed from the market in 2007 due to FDA concerns about possible adverse cardiovascular effects. Before then, it was the only drug approved by the United States Food and Drug Administration to help relieve the abdominal discomfort, bloating, and constipation associated with irritable bowel syndrome. Its use was also approved to treat chronic idiopathic constipation.[1][2] WP

Pharmacology

Mechanism of action

The drug functions as a motility stimulant, achieving its desired therapeutic effects through activation of the 5-HT₄ receptors of the enteric nervous system in the gastrointestinal tract. It also stimulates gastrointestinal motility and the peristaltic reflex, and allegedly reduces abdominal pain. Additionally, tegaserod is a 5-HT2B receptor antagonist.[3][4] WP

Chemistry

Formula
C16H23N5O PC
Molar mass (g/mol)
301.39 PC
IUPAC name (computed by PubChem)
1-[[(Z)-(5-methoxyindol-3-ylidene)methyl]amino]-2-pentylguanidine PC
SMILES
CCCCCN=C(N)NN/C=C/1\C=NC2=C1C=C(C=C2)OC PC
InChIKey
JWXDRFUZDKKGDV-VAWYXSNFSA-N PC
PubChem CID
5362436

Harm reduction information

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User reports

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Bluelight bluelight.org

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Pop culture

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Sources

  1. Other New Data for Zelnorm
  2. Journal / agency FDA approves first treatment for women with irritable-bowel syndrome
  3. Other Rossi, S. Australian Medicines Handbook. 2004
  4. Journal / agency Beattie DT, Smith JA, Marquess D, etal. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br. J. Pharmacol. November 2004. doi:10.1038/sj.bjp.0705929 · PMID 15466450 · PMC1575425

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.