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α2A-Adrenergic receptor agonist · Anxiolytic · Sedative · Hypnotic

Tasipimidine

Original Wikipedia articleen.wikipedia.org/wiki/Tasipimidine revision used (24 October 2026)

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Overview

Tasipimidine (INN (International Nonproprietary Name), USAN (United States Adopted Name); developmental code names ODM-105 and ORM-19695), sold under the brand name Tessie, is an α₂-adrenergic receptor agonist which is approved for the short-term treatment of fear and anxiety in dogs. It is also under development for the treatment of insomnia in humans. The drug is used as an oral solution in dogs, whereas its route of administration for humans is unspecified.[1–5] WP

The drug acts as a potent and selective full agonist of the human α2A-adrenergic receptor. Conversely, it is a much weaker agonist of the rodent α2B-, α2C-, and α2D-adrenergic receptors. In addition, it shows only low affinity for α₁-adrenergic receptors, where it appears to act as a partial agonist. Tasipimidine produces anxiolytic, sedative, hypolocomotor, hypotensive, and bradycardic effects in animals.[3] WP

Tasipimidine is under development for use in humans by Orion Corporation. As of October 2024, it is in phase 2 clinical trials for this indication. The drug is or was also under development for the treatment of psychiatric disorders in humans, but no recent development for this indication has been reported. It has reached phase 1 trials for psychiatric disorders. Tasipimidine was approved for treatment of fear and anxiety in dogs in the European Union in 2021.[1][4][5] WP

Drug class

α2A-Adrenergic receptor agonist Anxiolytic Sedative Hypnotic WP

From the Wikipedia article's infobox.

Chemistry

Formula
C13H16N2O2 PC
CAS number
1465908-70-6 PC
Molar mass (g/mol)
232.28 PC
IUPAC name (computed by PubChem)
2-(5-methoxy-3,4-dihydro-1H-isochromen-1-yl)-4,5-dihydro-1H-imidazole PC
SMILES
COC1=CC=CC2=C1CCOC2C3=NCCN3 PC
InChIKey
GHIKYGQWBRHEGU-UHFFFAOYSA-N PC
PubChem CID
71767208
IUPAC name
2-(5-methoxy-3,4-dihydro-1H-isochromen-1-yl)-4,5-dihydro-1H-imidazole WP

Harm reduction information

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Sources

  1. Other Tessie 0.3 mg/ml oral solution for dogs
  2. Journal / agency Kamutzki CJ, Emmerich IU. New drugs for small animals in 2024. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere. April 2025. doi:10.1055/a-2559-6314 · PMID 40233795
  3. Journal / agency Lehtimäki J, Jalava N, Unkila K, Aspegren J, Haapalinna A, Pesonen U. Tasipimidine-the pharmacological profile of a novel orally active selective α2A-adrenoceptor agonist. European Journal of Pharmacology. May 2022. doi:10.1016/j.ejphar.2022.174949 · PMID 35405115
  4. Journal / agency Tasipimidine. 28 October 2024
  5. Other Delving into the Latest Updates on Tasipimidine with Synapse. 28 June 2025

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.