Compound

Suriclone

Also called Suril, Celexane, 31264-RP

Original Wikipedia articleen.wikipedia.org/wiki/Suriclone revision used (24 October 2026)

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Overview

Suriclone (Suril) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and pagoclone. WP

Suriclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties but with less amnestic effects, and its chemical structure is quite different from that of the benzodiazepine drugs.[1][2] WP

The mechanism of action by which suriclone produces its sedative and anxiolytic effects is by modulating GABAA receptors, although suriclone is more subtype-selective than most benzodiazepines.[3] WP

Chemistry

Formula: C20H20ClN5O3S2 PC
CAS number: 53813-83-5 PC
Molar mass (g/mol): 478.0 PC
IUPAC name (computed by PubChem): [6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7-dihydro-2H-[1,4]dithiino[2,3-c]pyrrol-7-yl] 4-methylpiperazine-1-carboxylate PC
SMILES: CN1CCN(CC1)C(=O)OC2C3=C(C(=O)N2C4=NC5=C(C=C4)C=CC(=N5)Cl)SCCS3 PC
InChIKey: RMXOUBDDDQUBKD-UHFFFAOYSA-N PC
PubChem CID: 40903

Harm reduction information

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Sources

Journal / agency Gilburt SJ, Fairweather DB, Kerr JS, Hindmarch I. The effects of acute and repeated doses of suriclone on subjective sleep, psychomotor performance and cognitive function in young and elderly volunteers. Fundamental & Clinical Pharmacology. 1992. doi:10.1111/j.1472-8206.1992.tb00118.x · PMID 1362556
Journal / agency Saletu B, Grünberger J, Linzmayer L, Semlitsch HV, Anderer P, Chwatal K. Pharmacokinetic and -dynamic studies with a new anxiolytic, suriclone, utilizing EEG mapping and psychometry. British Journal of Clinical Pharmacology. February 1994. doi:10.1111/j.1365-2125.1994.tb04254.x · PMID 7910470 · PMC1364591
Journal / agency Blanchard JC, Julou L. Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum. Journal of Neurochemistry. March 1983. doi:10.1111/j.1471-4159.1983.tb08023.x · PMID 6298365

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