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Compound

Sulfinpyrazone

Also called Sulphinpyrazone, Anturane, Anturan

Original Wikipedia articleen.wikipedia.org/wiki/Sulfinpyrazone revision used (24 October 2026)

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Part of the metabolic pathway of Sulfinpyrazone. See the timeline on the metabolic highway.

Overview

Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane. WP

Like other uricosurics, sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney. WP

__TOC__ WP

Risks and side effects

Contraindications

Sulfinpyrazone must not be used in persons with renal impairment or a history of uric acid kidney stones.[1] WP

Research

Research

Trial have found that, Sulfinpyrazone taken in specific daily dose immediately following a patient having suffered from a myocardial infarction seem to drastically reduce the incidence of sudden death by as much as 43% and cardiac mortality by 32% in the 24 months following their heart attack.[2] WP

Chemistry

Formula
C23H20N2O3S PC
CAS number
57-96-5 PC
Molar mass (g/mol)
404.5 PC
IUPAC name (computed by PubChem)
4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione PC
SMILES
C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4 PC
InChIKey
MBGGBVCUIVRRBF-UHFFFAOYSA-N PC
PubChem CID
5342

Harm reduction information

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Sources

  1. Journal / agency Underwood M. Diagnosis and management of gout. BMJ. June 2006. doi:10.1136/bmj.332.7553.1315 · PMID 16740561 · PMC1473078
  2. Journal / agency Anturane Reinfarction Trial Research Group. Sulfinpyrazone in the Prevention of Sudden Death after Myocardial Infarction. New England Journal of Medicine. 1980-01-31. doi:10.1056/NEJM198001313020502 · PMID 6985706

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.