Compound

Spiperone

Also called Spiroperidol

Original Wikipedia articleen.wikipedia.org/wiki/Spiperone revision used (24 October 2026)

Why a "revision used" link? Anyone can edit Wikipedia at any time, so the article you open today may not say what it said when we read it. This link opens the exact version we read on 24 October 2026, frozen as it was. It is the only way to check that every quote on this page matches its source word for word. Newer versions may correct or change things. When we re-check this page against a newer version, the edit log records it. How we cite

Part of the metabolic pathway of Spiperone. See the timeline on the metabolic highway.

Overview

Spiperone, also known as spiroperidol and sold under the brand name Spiropitan ((JP)) is a typical antipsychotic of the butyrophenone family related to haloperidol. It is approved for clinical use in Japan as a treatment for schizophrenia.[1][2] WP

Pharmacology

Pharmacodynamics

Spiperone interacts with various monoamine receptors.[3][4][5] WP

Additionally, spiperone was identified by compound screening to be an activator of Ca²⁺ activated Cl⁻ channels (CaCCs), thus a potential target for therapy of cystic fibrosis.[6] WP

Chemistry

Formula: C23H26FN3O2 PC
CAS number: 749-02-0 PC
Molar mass (g/mol): 395.5 PC
IUPAC name (computed by PubChem): 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one PC
SMILES: C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(=O)C4=CC=C(C=C4)F PC
InChIKey: DKGZKTPJOSAWFA-UHFFFAOYSA-N PC
PubChem CID: 5265

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

Awaiting sourceChecked against PsychonautWiki and TripSit as each pull runs. This box is replaced as soon as a source has data.

User reports

Erowid erowid.org

Listings

Awaiting sourceExperience Vault listing and report categories.

Bluelight bluelight.org

Listings

Awaiting sourceTrip report threads and this substance's discussion forum.

Reddit reddit.com

Listings

Awaiting sourceTrip report posts and the relevant subreddits.

Pop culture

No references added yet.

Add a reference

Registered users can add songs, films, books, shows, games and art about this substance. Link a source that names the substance, such as the work's Wikipedia article, a review or an interview, not only the work itself. Entries are voted on and moderated like every other value on this page.

Opens when accounts launch.

Sources

Journal / agency Zheng LT, Hwang J, Ock J, Lee MG, Lee WH, Suk K. The antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide production. Journal of Neurochemistry. December 2008. doi:10.1111/j.1471-4159.2008.05675.x · PMID 18786164
Other Martindale: The Complete Drug Reference. 12 September 2011
Journal / agency Glennon RA. Central serotonin receptors as targets for drug research. J Med Chem. January 1987. doi:10.1021/jm00384a001 · PMID 3543362
Other Roth BL, Driscol J. PDSP Kᵢ Database. 12 January 2011
Journal / agency Janssen, P.A.J. Biochemical Immunological Pharmacology. 1982. doi:10.1016/b978-0-08-028024-0.50006-2
Journal / agency Liang L, MacDonald K, Schwiebert EM, Zeitlin PL, Guggino WB. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. American Journal of Physiology. Cell Physiology. January 2009. doi:10.1152/ajpcell.00346.2008 · PMID 18987251 · PMC4116347

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.