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Antineoplastic

Sonidegib

Also called Erismodegib, NVP-LDE225, Odomzo

Original Wikipedia articleen.wikipedia.org/wiki/Sonidegib revision used (24 October 2026)

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Part of the metabolic pathway of Sonidegib. See the timeline on the metabolic highway.

Enzymes that break it down: CYP3A. Wikipedia’s drug infobox says: “Liver (CYP3A)” (revision 1372709097).

Overview

Sonidegib (INN), sold under the brand name Odomzo, is a medication used to treat cancer.[1] WP

Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism).[2][3] WP

Drug class

Antineoplastic WP

From the Wikipedia article's infobox.

Pharmacology

Pharmacology

Sonidegib is administered by mouth. Common side effects include muscle spasms, hair loss, fatigue, abdominal pain, nausea, headache, and weight loss.[1] WP

Sonidegib binds to and inhibits smoothened to inhibit activation of the Hedgehog pathway. Sonidegib is primarily metabolized by CYP3A and is eliminated hepatically.[1] WP

Chemistry

Formula
C26H26F3N3O3 PC
CAS number
956697-53-3 PC
Molar mass (g/mol)
485.5 PC
IUPAC name (computed by PubChem)
N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3-pyridinyl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide PC
SMILES
C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F PC
InChIKey
VZZJRYRQSPEMTK-CALCHBBNSA-N PC
PubChem CID
24775005

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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Sources

  1. Journal / agency Odomzo- sonidegib capsule. 29 May 2019
  2. Journal / agency LDE225 - PubChem
  3. Journal / agency Pan S, Wu X, Jiang J, Gao W, Wan Y, Cheng D, Han D, Liu J, Englund NP, Wang Y, Peukert S, Miller-Moslin K, Yuan J, Guo R, Matsumoto M, Vattay A, Jiang Y, Tsao J, Sun F, Pferdekamper AC, Dodd S, Tuntland T, Maniara W, Kelleher JF, Yao YM, Warmuth M, Williams J, Dorsch M. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Medicinal Chemistry Letters. June 2010. doi:10.1021/ml1000307 · PMID 24900187 · PMC4007689

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.