Selective serotonin reuptake inhibitor
Overview
Selective serotonin reuptake inhibitors (commonly abbreviated as SSRIs) are a class of pharmaceutical antidepressant medications. They are commonly prescribed for the treatment of major depressive disorders. Other conditions include anxiety disorders, obsessive-compulsive disorder, migraine, attention-deficit hyperactivity disorder (ADHD), addiction/dependence, and sleep disorders. The exact pharmacological mechanism of action of SSRIs is unknown. They are believed to increase the extracellular level of the neurotransmitter serotonin, eventually leading to improved mood.[1] PW⚠ PsychonautWiki itself has flagged this text: citation needed.⚠ PsychonautWiki itself has flagged this text: clarification needed.
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychiatric conditions. WP
SSRIs primarily work by blocking serotonin reabsorption (reuptake) via the serotonin transporter, leading to gradual changes in brain signaling and receptor regulation, with some also interacting with sigma-1 receptors, particularly fluvoxamine, which may contribute to cognitive effects. Marketed SSRIs include six main antidepressants—citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline—and dapoxetine, which is indicated for premature ejaculation. Fluoxetine has been approved for veterinary use in the treatment of canine separation anxiety. WP
SSRIs are the most widely prescribed antidepressants in many countries. In adults, they are recommended as a first-line treatment for moderate to severe depression, while for mild depression non-drug treatments are preferred unless the patient chooses medication. A 2018 meta analysis of 21 antidepressants showed that all antidepressants (including SSRIs) were more effective than placebo in adults with major depressive disorder.[2]
Drugs in this class on intoxicant.wiki
Every page on this site that a cited source puts in this class: 8 pages. A drug is listed when PsychonautWiki's "Selective serotonin reuptake inhibitor" page, revision 162817 lists it, or when its own PsychonautWiki, TripSit or Wikipedia entry names this class. Each name opens our page for that drug; long chemical names are shown by a shorter name the drug is also known by (hover for the full name).
- 6-Chloro-2-(1-piperazinyl)quinoxaline WP
- BMS-505130 WP
- Citalopram PW list TS
- Escitalopram PW list TS
- Fluoxetine PW list TS
- Fluvoxamine PW list TS
- Paroxetine PW list TS WP
- Sertraline PW list TS
Tags show who puts each drug in this class (hover for the exact wording): PW list = listed on PsychonautWiki's page for this class; PW = the drug's PsychonautWiki entry; TS = the drug's TripSit entry (drug category); WP = the drug infobox of the drug's Wikipedia article. These are classifications only, not dosage guidance.
References
- Other page 20
- Other Preskorn SH, Ross R, Stanga CY. Antidepressants: Past, Present and Future. 2004
- Other Recommendations | Depression in adults: treatment and management | Guidance | NICE. 2022-06-29
- Journal / agency Cipriani, Andrea; Furukawa, Toshi A.; Salanti, Georgia; Chaimani, Anna; Atkinson, Lauren Z.; Ogawa, Yusuke; Leucht, Stefan; Ruhe, Henricus G.; Turner, Erick H.; Higgins, Julian P. T.; Egger, Matthias; Takeshima, Nozomi; Hayasaka, Yu; Imai, Hissei; Shinohara, Kiyomi. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. The Lancet. 2018-04-07. doi:10.1016/S0140-6736(17)32802-7 · PMID 29477251 · PMC5889788
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