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Compound

Roxatidine acetate

Also called Aceroxatidine, Roxane

Original Wikipedia articleen.wikipedia.org/wiki/Roxatidine_acetate revision used (24 October 2026)

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Part of the metabolic pathway of Roxatidine acetate. See the timeline on the metabolic highway.

Enzymes that break it down: CYP2D6 and CYP2A6. Wikipedia’s drug infobox says: “Hepatic deacetylation; Minor involvement of CYP2D6 and CYP2A6” (revision 1330111613).

Overview

Roxatidine acetate is a specific and competitive histamine H₂ receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.[1][2] WP

Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.[1] WP

It was patented in 1979 and approved for medical use in 1986. It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece, and South Africa.[2][3] WP

Chemistry

Formula
C19H28N2O4 PC
CAS number
78628-28-1 PC
Molar mass (g/mol)
348.4 PC
IUPAC name (computed by PubChem)
[2-oxo-2-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]ethyl] acetate PC
SMILES
CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2 PC
InChIKey
SMTZFNFIKUPEJC-UHFFFAOYSA-N PC
PubChem CID
5105

Harm reduction information

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Sources

  1. Journal / agency Murdoch D, McTavish D. Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs. August 1991. doi:10.2165/00003495-199142020-00006 · PMID 1717223
  2. Other BioSpectrum Bureau 1 November 2012 Sinhuan's generic heart drug gets production approval
  3. Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.