intoxicant.wiki2catechol4school
Compound

Romifidine

Also called Sedivet

Original Wikipedia articleen.wikipedia.org/wiki/Romifidine revision used (24 October 2026)

Why a "revision used" link? Anyone can edit Wikipedia at any time, so the article you open today may not say what it said when we read it. This link opens the exact version we read on 24 October 2026, frozen as it was. It is the only way to check that every quote on this page matches its source word for word. Newer versions may correct or change things. When we re-check this page against a newer version, the edit log records it. How we cite

Overview

Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses, although it may be used in a wide variety of species. It is not used in humans, but is closely related in structure to the commonly used drug clonidine.[1][2][3] WP

Romifidine acts as an agonist at the α₂ adrenergic receptor subtype. Side effects can include bradycardia and respiratory depression. It is often used alongside other sedative or analgesic drugs such as ketamine or butorphanol. Yohimbine can be used as an antidote to rapidly reverse the effects.[4][5] WP

Uses, dosage and effects

Use

Romifidine is licensed for cats and dogs in several countries. Romifidine is licensed for non-meat horses. Romifidine may produce less ataxia during standing sedation than other α₂-adrenergic receptor agonists.[6] WP

Risks and side effects

Side effects

Romifidine administration in sheep activates pulmonary macrophages that damage the endothelium of capillaries and alveolar type I cells. This in turns causes alveolar haemorrhage and oedema causing hypoxaemia.[6][7][8] WP

Pharmacology

Pharmacology

Romifidine is an α₂-adrenergic receptor agonist that binds at a ratio of 340:1 over the imidazoline receptor.[6] WP

Chemistry

Formula
C9H9BrFN3 PC
CAS number
65896-16-4 PC
Molar mass (g/mol)
258.09 PC
IUPAC name (computed by PubChem)
N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine PC
SMILES
C1CN=C(N1)NC2=C(C=CC=C2Br)F PC
InChIKey
KDPNLRQZHDJRFU-UHFFFAOYSA-N PC
PubChem CID
71969
IUPAC name
N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine WP

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

Awaiting sourceChecked against PsychonautWiki and TripSit as each pull runs. This box is replaced as soon as a source has data.

User reports

Erowid erowid.org

Listings
Awaiting sourceExperience Vault listing and report categories.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Bluelight bluelight.org

Listings
Awaiting sourceTrip report threads and this substance's discussion forum.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Reddit reddit.com

Listings
Awaiting sourceTrip report posts and the relevant subreddits.
Top stories
Awaiting sourceShort summaries of the most-read reports, each linked, saying only what the report says.

Pop culture

No references added yet.

Add a reference

Registered users can add songs, films, books, shows, games and art about this substance. Link a source that names the substance, such as the work's Wikipedia article, a review or an interview, not only the work itself. Entries are voted on and moderated like every other value on this page.

Opens when accounts launch.

Sources

  1. Journal / agency Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses. American Journal of Veterinary Research. November 2005. doi:10.2460/ajvr.2005.66.1992 · PMID 16334961
  2. Journal / agency De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine. February 2007. doi:10.1111/j.1439-0442.2007.00910.x · PMID 17359455
  3. Journal / agency Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. The Veterinary Record. January 2008. doi:10.1136/vr.162.3.82 · PMID 18204032
  4. Journal / agency Corletto F, Raisis AA, Brearley JC. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. Veterinary Anaesthesia and Analgesia. January 2005. doi:10.1111/j.1467-2995.2004.00184.x · PMID 15663735
  5. Journal / agency Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. Canadian Journal of Veterinary Research. October 2004. PMID 15581222 · PMC1111358
  6. Other Lamont LA, Creighton CM. Veterinary Anesthesia and Analgesia, The 6th Edition of Lumb and Jones. 11 September 2024
  7. Journal / agency CS C, OS A, WN M, WD B. Histopathologic alterations induced in the lungs of sheep by use of alpha2-adrenergic receptor agonists. American Journal of Veterinary Research. Feb 1999. doi:10.2460/ajvr.1999.60.02.154 · PMID 10048544
  8. Journal / agency Celly C, McDONELL W, Young S, Black W. The comparative hypoxaemic effect of four α 2 adrenoceptor agonists (xylazine, romifidine, detomidine and medetomidine) in sheep. Journal of Veterinary Pharmacology and Therapeutics. 1997. doi:10.1046/j.1365-2885.1997.00097.x · PMID 9430770

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.