Rolicyclidine

Dosage

Oral

TripSit dose text

TripSit's factsheet also states its doses as text.

Light: 2-4mg Common: 4-8mg Strong: 8mg+ TS

Duration

TripSit factsheet

Onset

Insufflated: 30 minutes · Oral: 30-60 minutes TS

Duration

2-6 hours TS

Aftereffects

1-8 hours TS

Mixing

Acute combinations: what happens when these are taken close together. Entries backed by a medical journal or agency are listed first.

Backed by medical journals

Other documented combinations

• Dangerous Opioids - Opioids add to the central depressant action of PCPy, easily producing unconsciousness at higher doses PW
• Dangerous 2C-T-x PW
• Dangerous ΑMT PW
• Dangerous 5-MeO-xxT PW
• Dangerous GHB - Details of this combination are not well understood but PCPy generally interacts in an unpredictable manner. PW
• Dangerous GBL - Details of this combination are not well understood but PCPy generally interacts in an unpredictable manner. PW
• Dangerous Tramadol PW
• Dangerous MAOIs - Stimulatory effects as are produced by this class of compounds are innately dangerous with MAO inhibition, potential serotonergic effects are deadly with MAO inhibition. PW
• Unsafe DOx - Details of this combination are not well understood but PCPy generally interacts in an unpredictable manner. PW
• Unsafe Amphetamines - This combination can easily lead to hypermanic states. PW
• Unsafe MDMA - This combination can easily lead to hypermanic states. PW
• Unsafe Cocaine - This combination can easily lead to hypermanic states. PW
• Unsafe Alcohol - Adds to the central depressant effect of PCPy, dangerous at high dosages. PW
• Unsafe Benzodiazepines - Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely. Small amounts of benzodiazepines might end a bad trip. PW
• Unsafe SSRIs - Details of this combination are not well understood but PCPy generally interacts in an unpredictable manner. PW
• Unsafe DXM - Unnecessary as it might produce unpleasant effects such as dizziness or nausea, but may at the same time increase visuals and or dissociation. PW
• Uncertain MXE - PCPy generally potentiates the action of other arylcyclohexylamine dissociatives. PW
• Uncertain Caffeine - Details of this combination are not well understood but PCPy generally interacts in an unpredictable manner. PW

Risks and toxicity

The long-term use of substances of the PCP class may lead to schizophrenia-like psychotic episodes, severe lasting memory loss, disorganized thinking, depression, weight loss, liver abnormalities and rhabdomyolysis (skeletal muscle breakdown).[5] PW

It is very strongly recommended that one use extreme caution and harm reduction practices when using this substance. For example, PW

• The biggest danger with this family of compounds is their potency, coupled with their duration of action and their propensity to cause bizarre manic states at higher dosages, start low and go slow if you are unfamiliar with its effects, by itself PCPy, if used carefully, is not any more dangerous than other more well known drugs. PW
• Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects. PW
• The recommended dosage range should not be exceeded as high doses can trigger adverse effects. PW
• Users should start with extremely low doses and work their way up as slowly as possible. Volumetric liquid dosing should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg. PW
• Compulsive redosing before one has fully sobered up is not recommended and can result in too high of a dose. PW

Psychosis

PCPy, like its parent, has been reported to cause psychosis and mania at a significantly higher rate than other dissociatives such as ketamine, diphenidine, or MXE. Multiple scientific papers describe states of psychosis, mania, and/or delirium occurring after moderate to large doses of the parent compound. PW

Due to the risk of psychosis, it is not recommended to combine this substance with other substances, especially stimulants, psychedelics, or other dissociatives like MXE and DXM. PW

Neurological effects

Some studies found that, like other NMDA receptor antagonists, PCPy can cause brain damage called Olney's lesions in rats. Studies conducted on rats showed that high doses of the NMDA receptor antagonist dizocilpine caused reversible vacuoles to form in certain regions of the rats' brains. All studies of Olney's lesions have only been performed on non-human animals and may not apply to humans.[6][7] PW

One unpublished study by Frank Sharp reportedly showed no damage by the NMDA antagonist ketamine (a similar drug) far beyond recreational doses but its validity is controversial since it was never published.[8] PW

PCP-type compounds have also been shown to cause schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate levels in the rat brain, which are detectable both in living rats and upon necropsy examination of brain tissue. Rolicyclidine, like its parent, PCP, probably induces schizomimetic effects in humans.[9][10] PW

Urinary tract effects

In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, PCP-type compounds seem to have similar toxic effects as ketamine but as much lower dosages are usually employed it has less of a propensity to cause toxic effects, accumulate or present severe metabolic load. PW

• Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes. PW
• Urinary urgency - This can be described as a sudden, compelling need to urinate. PW
• Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination. PW
• Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine. PW
• Hematuria - Hematuria is visible blood in the urine. PW
• Incontinence - This is the uncontrolled leakage of urine. PW

Dependence and abuse potential

The chronic use of PCPy can be considered highly addictive with a high potential for adverse side effects such as psychosis. In comparison to other dissociatives, PCPy has been reported to be more addictive than MXE, diphenidine, ephenidine, and ketamine. PW

When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance. PW

Tolerance to many of the effects of PCPy develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). PCPy presents cross-tolerance with all dissociatives, meaning that after the consumption of PCPy, all dissociatives will have a reduced effect. PW

TripSit factsheet

Avoid

All CNS depressants. TS

Testing

User reports