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Typical antipsychotic

Promazine

Also called Ampazine, Promwill, Romtiazin

Original Wikipedia articleen.wikipedia.org/wiki/Promazine revision used (24 October 2026)

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Part of the metabolic pathway of Promazine. See the timeline on the metabolic highway.

Overview

Promazine (brand name Sparine among others), is used as a short-term add-on treatment for psychomotor agitation. Its approved uses in people is limited, but is used as a tranquilizer in veterinary medicine. It has weak antipsychotic effects but is generally not used to treat psychosis.[1][2][3] WP

It acts similar to chlorpromazine and causes sedation. It has predominantly anticholinergic side effects, though extrapyramidal side effects are not uncommon. It belongs to the typical antipsychotic and phenothiazine class of drugs.[2][4] WP

Promazine was approved for medical use in the United States in the 1950s, although it is no longer commercially available there.[1][5] WP

Drug class

Typical antipsychotic WP

From the Wikipedia article's infobox.

Uses, dosage and effects

Uses

Promazine is a short-term add-on treatment for psychomotor agitation.[3] WP

Risks and side effects

Adverse effects

Common side effects include agitation, amenorrhea, arrhythmias, constipation, drowsiness and dizziness, dry mouth, impotence, tiredness, galactorrhoea, gynecomastia, hyperglycemia, insomnia, hypotension, prolonged QT, seizures, tremor, vomiting and weight gain, among others.[3] WP

Overdose

In overdose, it may cause hypotension, hypothermia, tachycardia, and arrhythmia.[3] WP

Sudden death may occur, although rare.[3] WP

Median lethal dose (LD50) in animals

Quoted from PubChem's Non-Human Toxicity Values, which come from the Hazardous Substances Data Bank (HSDB). PubChem describes them as: “Quantitative non-human toxicity values (e.g., lethal dose) for this compound. The data shown here are mostly for lab animals (e.g., rat, mouse, guinea pig, and rabbit).” and defines the “LD50 (median lethal dose, the estimated amount of a chemical expected to kill 50% of test animals in a single dose)”. PC

LD50 (as the source gives it)Reference
LD50 Rat oral 350 mg/kg PCLewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1293 (via HSDB record 3172)
LD50 Rat sc 192 mg/kg PCLewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1293 (via HSDB record 3172)
LD50 Rat iv 14,500 ug/kg PCLewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1293 (via HSDB record 3172)
LD50 Mouse oral 401 mg/kg PCLewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1293 (via HSDB record 3172)

Chemistry

Formula
C17H20N2S PC
CAS number
58-40-2 PC
Molar mass (g/mol)
284.4 PC
IUPAC name (computed by PubChem)
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine PC
SMILES
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31 PC
InChIKey
ZGUGWUXLJSTTMA-UHFFFAOYSA-N PC
PubChem CID
4926
IUPAC name
N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine WP

Harm reduction information

No harm reduction data is on file for this compound yet. That means no dose, timing or combination data from PsychonautWiki or TripSit. Please don't guess a dose from similar compounds. If you have taken it and feel unwell, contact emergency services or a poison control center.

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Pop culture

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Sources

  1. Other Promazine (Primazine, Prozine)
  2. Journal / agency Davis C. X Pharm: The Comprehensive Pharmacology Reference. 2007. doi:10.1016/B978-008055232-3.62472-9
  3. Other BNF
  4. Other Pagliaro LA, Pagliaro AM. Psychologist's Neuropsychotropic Desk Reference. 1999
  5. Journal / agency Drugs@FDA: FDA-Approved Drugs

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.