Compound

Pranlukast

Also called Azlaire, Ono-RS-411, Onon

Original Wikipedia articleen.wikipedia.org/wiki/Pranlukast revision used (24 October 2026)

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Part of the metabolic pathway of Pranlukast. See the timeline on the metabolic highway.

Enzymes that break it down: CYP3A4. Wikipedia’s drug infobox says: “Hepatic (mainly CYP3A4)” (revision 1332213073).

Overview

Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan. WP

Medications of this class, which go under a variety of names according to whether one looks at the American, British or European system of nomenclature, have as their primary function the antagonism of bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.[1] WP

Medications of this group are normally used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. There are several similar medications in the group; all appear to be equally effective. Pranlukast is also reported as potential inhibitor of Mycobacterium tuberculosis infection in experimental models.[2] WP

Chemistry

Formula: C27H23N5O4 PC
CAS number: 103177-37-3 PC
Molar mass (g/mol): 481.5 PC
IUPAC name (computed by PubChem): N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide PC
SMILES: C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC=CC4=C3OC(=CC4=O)C5=NNN=N5 PC
InChIKey: NBQKINXMPLXUET-UHFFFAOYSA-N PC
PubChem CID: 4887

Harm reduction information

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Sources

Journal / agency Singh RK, Tandon R, Dastidar SG, Ray A. A review on leukotrienes and their receptors with reference to asthma. The Journal of Asthma. November 2013. doi:10.3109/02770903.2013.823447 · PMID 23859232
Journal / agency Mishra A, Mamidi AS, Rajmani RS, Ray A, Roy R, Surolia A. An allosteric inhibitor of Mycobacterium tuberculosis ArgJ: Implications to a novel combinatorial therapy. EMBO Molecular Medicine. April 2018. doi:10.15252/emmm.201708038 · PMID 29483133 · PMC5887547

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.