Compound

Potassium canrenoate

Also called Kanrenol, Spiroctan-m, Soludactone

Original Wikipedia articleen.wikipedia.org/wiki/Potassium_canrenoate revision used (24 October 2026)

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Part of the metabolic pathway of Potassium canrenoate. See the timeline on the metabolic highway.

Overview

Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), also known as aldadiene kalium, the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group. Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body.[1–4] WP

Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous) as opposed to oral administration.[4][5][6] WP

In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring. WP

Chemistry

Formula: C22H29KO4 PC
CAS number: 2181-04-6 PC
Molar mass (g/mol): 396.6 PC
IUPAC name (computed by PubChem): potassium 3-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoate PC
SMILES: C[C@]12CCC(=O)C=C1C=C[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(CCC(=O)[O-])O)C.[K+] PC
InChIKey: JTZQCHFUGHIPDF-RYVBEKKQSA-M PC
PubChem CID: 23671691

Harm reduction information

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Sources

Other Selye H. Hormones and Resistance: Part 1 and. 17 April 2013
Other Hill RA, Makin HL, Kirk DN, Murphy GM. Dictionary of Steroids. 23 May 1991
Other Burger A, Wolff ME. Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents. 1996
Other Waldmann C, Soni N, Rhodes A. Oxford Desk Reference: Critical Care. 27 November 2008
Other Santambrogio R, Barabino M, Opocher E. Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES). 21 June 2017
Journal / agency Kolkhof P, Bärfacker L. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development. The Journal of Endocrinology. July 2017. doi:10.1530/JOE-16-0600 · PMID 28634268 · PMC5488394

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.