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Compound

Piretanide

Also called Arlix, Arelix, Tauliz

Original Wikipedia articleen.wikipedia.org/wiki/Piretanide revision used (24 October 2026)

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Part of the metabolic pathway of Piretanide. See the timeline on the metabolic highway.

Overview

Piretanide is a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups. Studies of piretanide in rats and dogs in comparison with other high-ceiling diuretics such as furosemide and bumetanide found a more suitable dose/response rate (regression line) and a more favourable sodium/potassium excretion ratio. These findings led eventually to studies in man and finally to the introduction as a saluretic and antihypertensive medication in Germany, France, Italy and other countries.[1][2] WP

It was made in 1973, patented in 1974, and approved for medical use in 1981.[3] WP

Chemistry

Formula
C17H18N2O5S PC
CAS number
55837-27-9 PC
Molar mass (g/mol)
362.4 PC
IUPAC name (computed by PubChem)
4-phenoxy-3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid PC
SMILES
C1CCN(C1)C2=C(C(=CC(=C2)C(=O)O)S(=O)(=O)N)OC3=CC=CC=C3 PC
InChIKey
UJEWTUDSLQGTOA-UHFFFAOYSA-N PC
PubChem CID
4849

Harm reduction information

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Sources

  1. Journal / agency Musini VM, Rezapour P, Wright JM, Bassett K, Jauca CD. Blood pressure-lowering efficacy of loop diuretics for primary hypertension. The Cochrane Database of Systematic Reviews. May 2015. doi:10.1002/14651858.CD003825.pub4 · PMID 26000442 · PMC7156893
  2. Other Austria-Codex. 2009
  3. Other Fischer J, Ganellin CR. Analogue-based Drug Discovery. 2006

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.