Antihistamine · H1 receptor antagonist

Phenbenzamine

Also called Antergan, Lergitin, Bridal

Original Wikipedia articleen.wikipedia.org/wiki/Phenbenzamine revision used (24 October 2026)

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Overview

Phenbenzamine, sold under the brand name Antergan and known by the former developmental code name RP-2339, is an antihistamine of the ethylenediamine class which also has anticholinergic properties. It was introduced in 1941 or 1942 and was the first antihistamine to be introduced for medical use. Soon following its introduction, phenbenzamine was replaced by another antihistamine of the same class known as mepyramine (pyrilamine; Neoantergan). Following this, other antihistamines, such as diphenhydramine, promethazine, and tripelennamine, were developed and introduced. Owing to their sedative effects, phenbenzamine and promethazine were assessed in the treatment of bipolar disorder in France in the 1940s and were regarded as promising therapies for such purposes. Whereas phenbenzamine was the first clinically useful antihistamine, piperoxan was the first compound with antihistamine properties to be discovered and was synthesized in the early 1930s.[1–7] WP

Drug class

Antihistamine H1 receptor antagonist WP

From the Wikipedia article's infobox.

Chemistry

Formula: C17H22N2 PC
CAS number: 961-71-7 PC
Molar mass (g/mol): 254.37 PC
IUPAC name (computed by PubChem): N'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine PC
SMILES: CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=C2 PC
InChIKey: CHOBRHHOYQKCOU-UHFFFAOYSA-N PC
PubChem CID: 13751
IUPAC name: N-(2-Dimethylaminoethyl)-N-benzylaniline WP

Harm reduction information

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Sources

Other Phenbenzamine
Other Maxwell RA, Eckhardt SB. Drug Discovery: A Casebook and Analysis. 6 December 2012
Journal / agency Moncrieff, Joanna. The Bitterest Pills. 2013. doi:10.1057/9781137277442_2
Other Williams DA, Foye WO, Lemke TL. Foye's Principles of Medicinal Chemistry. 2002
Other Welcome MO. Gastrointestinal Physiology: Development, Principles and Mechanisms of Regulation. 20 June 2018
Other Cundell DR, Mickle KE. Frontiers in Clinical Drug Research - Anti-Allergy Agents. 11 July 2018
Other Landau R, Achilladelis B, Scriabine A. Pharmaceutical Innovation: Revolutionizing Human Health. 1999

Text and values on this page are quoted from Wikipedia (CC BY-SA 4.0), PubChem (public domain). Each value links to the exact revision it came from.